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Radiotracer Imaging of Skeletal Muscle Perfusion in Patients With Peripheral Artery Disease

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities in skeletal muscle perfusion and evaluating responses to medical treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• At least 18 years of age

• Evidence of significant obstructive disease for one or multiple lower extremity arteries, as identified by prior ABI, TBI, CT angiography, ultrasound, or MR imaging.

• At least 18 years of age

• No evidence or prior diagnosis of peripheral artery disease based on chart review and standard vascular screening.

Locations
United States
Ohio
Nationwide Children's Hospital
RECRUITING
Columbus
Contact Information
Primary
Mitchel R Stacy, Ph.D.
Mitchel.Stacy@nationwidechildrens.org
614-355-5836
Time Frame
Start Date: 2017-02-17
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 192
Treatments
Experimental: SPECT/CT perfusion imaging
Patients with peripheral artery disease will have already been scheduled for clinically indicated revascularization procedures of the lower extremity and undergo SPECT/CT imaging as part of the research protocol.
Experimental: PET/CT perfusion imaging
Patients with peripheral artery disease will have already been scheduled for clinically indicated revascularization procedures of the lower extremity and undergo PET/CT imaging as part of the research protocol.
Sponsors
Leads: Nationwide Children's Hospital
Collaborators: Ohio State University

This content was sourced from clinicaltrials.gov