A Multicenter, Randomized, Single-Blind, Phase Ⅱ Clinical Trial and Open Label Long-term Observation Study of ADSTEM Inj. to Evaluate the Safety and Efficacy in Patients With Moderate to Severe Subacute and Chronic Atopic Dermatitis

Who is this study for? Patients with secondary or above subacuteal and chronic Atopic Dermatitis
What treatments are being studied? ADSTEM
Status: Active_not_recruiting
Location: See all (6) locations...
Intervention Type: Biological, Other
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

A Multicenter, Randomized, Single-Blind, Phase Ⅱ Clinical Trial and Open Label Long-term Observation Study of ADSTEM Inj. to Evaluate the Safety and Efficacy in Patients with Moderate to Severe Subacute and Chronic Atopic Dermatitis. The aim of this study is to evaluate the safety and efficacy of ADSTEM Inj. against Placebo in the treatment of atopic dermatitis in patients with moderate to severe acute and chronic atopic.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Maximum Age: 70
Healthy Volunteers: f
View:

• At the time of visit 1, only men and women aged between 19 and 70

• Patients with atopic dermatitis meeting the Hanifin and Rajka diagnostic criteria

• Subacute and chronic patients with symptoms of atopic dermatitis lasting at least 6 months

• Patients with moderate to severe atopic dermatitis who meet all of the following criteria

‣ SCORAD score ≥ 20points

⁃ EASI score ≥ 12points

⁃ BSA ≥ 10%

• Patients with inadequate response to the stable use of topical atopic dermatitis treatment within 24 weeks prior to study initiation, or those who are unable to administer topical atopic dermatitis treatment due to safety reasons

• Patients who voluntarily agreed in writing to participate in this clinical trial

Locations
Other Locations
Republic of Korea
Korea University AnSan Hospital
Ansan
Chungnam National University Hospital
Daejeon
Chung-Ang University Hospital
Seoul
Kyunghee University Medical Center
Seoul
Seoul National University Hospital
Seoul
SMG-SNU Boramae Medical Center
Seoul
Time Frame
Start Date: 2019-12-11
Completion Date: 2027-10-31
Participants
Target number of participants: 118
Treatments
Experimental: ADSTEM Inj.
ADSTEM Inj. hAD-MSC 1.0x10\^8 cells
Placebo_comparator: Placebo
0.9% Normal Saline Inj.
Related Therapeutic Areas
Sponsors
Leads: EHL Bio Co., Ltd.

This content was sourced from clinicaltrials.gov

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