What is the definition of Attenuated Familial Adenomatous Polyposis?

Attenuated familial adenomatous polyposis (AFAP) is an inherited condition that increases the chance to develop cancer of the large intestine (colon) and rectum. It is a milder form of classic familial adenomatous polyposis (FAP) and is characterized by fewer colon polyps (an average of 30) and a delay in the development of colon cancer (average age 50 to 55 years). Other signs and symptoms may include benign or malignant tumors of the duodenum (a section of the small intestine) and, in rare cases, other symptoms of FAP. AFAP is caused by mutations in the APC gene and is inherited in an autosomal dominant manner. AFAP is generally managed with regular screening to detect if and when polyps develop.

What are the alternative names for Attenuated Familial Adenomatous Polyposis?

  • Attenuated FAP
  • AFAP
  • Mild form of FAP
  • Attenuated familial polyposis coli
  • Attenuated adenomatous polyposis coli
  • AAPC

What are the current treatments for Attenuated Familial Adenomatous Polyposis?

Treatment of familial adenomatous polyposis (FAP) is focused on managing the risk for colon cancer.  Screening for colon cancer and polyps by endoscopy may begin in childhood. There is the option to remove the colon (colectomy) before colon cancer develops. The timing of this surgery is based on multiple factors. Guidelines for treatment and management of FAP and other polyposis conditions have been developed and published.

Specialists involved in the care of someone with familial adenomatous polyposis may include:
  • Medical geneticist
  • Gastroenterologist
  • Surgeon
  • Orthopedic surgeon
  • Ophthalmologist
  • Dentist

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.