Magnetic Resonance Imaging Neuroanatomical Study of Patients with an Autism Spectrum Disorder, Their Relatives and Typically Developing Subjects.

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

This project is structured around a central study called Study of genetic factors involved in autism and related conditions (Genes and Autism study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD. In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD. This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD Secondary objectives include: * the identification of familial heritability patterns of ASD * correlate data obtained in brain imaging with genetic data * assess specificity and statistical reproducibility of the obtained results

Eligibility
Participation Requirements
Sex: All
Minimum Age: 2
Healthy Volunteers: t
View:

• for patients:

‣ being included in the main study C16-89 - Study of genetic factors involved in ASD and related disorders

⁃ having an ASD fulfilling DSM-5 diagnostic criteria (APA, 2012). Diagnosis will be done by a clinical expert, with the support of structured instruments (ADI-R, ADOS-2)

⁃ having at least 24 Months

⁃ being affiliated with the French health insurance

⁃ having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)

• for relatives

‣ being included in the main study C16-89 - Study of genetic factors involved in ASD and related disorders

⁃ having at least 24 Months

⁃ being affiliated with the French health insurance

⁃ having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)

• for controls

‣ being included in the main study C16-89 - Study of genetic factors involved in ASD and related disorders

⁃ having at least 24 Months

⁃ being affiliated with the French health insurance

⁃ having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)

Locations
Other Locations
France
NeuroSpin neuroimaging platforme
NOT_YET_RECRUITING
Gif-sur-yvette
APHP, Hôpital Robert Debré
RECRUITING
Paris
Contact Information
Primary
Richard Delorme, M.D, Ph.D
richard.delorme@aphp.fr
+33140032002
Backup
Josselin Houenou, M.D, Ph.D
josselin.houenou@inserm.fr
+33149813051
Time Frame
Start Date: 2022-03-13
Estimated Completion Date: 2039-09-13
Participants
Target number of participants: 1000
Treatments
Subjects with Autism Spectrum Disorders
Relatives of subjects with Autism Spectrum Disorders
Typically developing subjects
Related Therapeutic Areas
Sponsors
Collaborators: APHP, Commissariat A L'energie Atomique, Institut Pasteur
Leads: Institut National de la Santé Et de la Recherche Médicale, France

This content was sourced from clinicaltrials.gov