Discerning the Abnormal Functional Connectivity Involving the Social Reciprocity Network in Autism Spectrum Disorder and the Impact of Transcranial Magnetic Stimulation in Mitigating the Abnormalities

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of social reciprocity network and hypothesize that aberrant connectivity/oscillatory patterns affecting this network contribute to the core deficits in ASD. The overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence/spectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 13
Maximum Age: 18
Healthy Volunteers: f
View:
Locations
United States
Delaware
Christiana Care
RECRUITING
Newark
Contact Information
Primary
Mitra Assadi, MD
mitra.assadi@christianacare.org
3026233017
Backup
Ryan Ally, MD
ryan.ally@christianacare.org
302-320-2100
Time Frame
Start Date: 2024-08-15
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 12
Treatments
Sham_comparator: phase 1
During phase I (3 weeks), half of the subjects will receive rTMS, while the other half will receive sham stimulation.
Active_comparator: phase 2
During phase II (3 weeks) all subjects will receive active stimulation.
Related Therapeutic Areas
Sponsors
Leads: Christiana Care Health Services

This content was sourced from clinicaltrials.gov