Feasibility and Efficacy of rTMS in Depression in Individuals With Autism Spectrum Disorder (ASD)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Depression is a common complication of Autism Spectrum Disorder (ASD): it is four times more prevalent in people with ASD than in the general population. However, treating depression in people with ASD is complicated by the lack of guidelines. Antidepressants appear to be less effective and less well tolerated than in the general population. rTMS (repetitive transcranial magnetic stimulation) is a technique that stimulates the brain in a painless and non-invasive way. This technique is well tolerated and has very few side effects (headaches, fatigue). It is now used routinely in clinical practice to treat resistant depression, with satisfactory results. A few studies using rTMS in depression in people with ASD have shown encouraging results and avenues for improvement. It could therefore be interesting to conduct a therapeutic study with rTMS on depression in people with ASD, following the avenues for improvement proposed by previous studies. The main objective is to evaluate the effectiveness of rTMS in depressed patients with ASD by looking at changes in mood before and after treatment. The investigator will also look at the effects on executive and attentional functions and repetitive behaviors, as well as treatment tolerance.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Patient with a diagnosis of ASD validated by a psychiatrist or line 2

• Patient aged 18 to 65...

• Patients suffering from EDM (MADRS greater than 20)

• No change in treatment in the month prior to inclusion

• Patients affiliated with or entitled to social security

• Patients who have received informed information about the study and have signed a consent form to participate in the study

Locations
Other Locations
France
Centre Hospitalier Guillaume Régnier
RECRUITING
Rennes
Time Frame
Start Date: 2024-12-19
Estimated Completion Date: 2026-02-19
Participants
Target number of participants: 25
Treatments
Experimental: ASD patients with depression
Patients receive 4 sessions of 10 minutes per day with a 50-minute interval between each session
Related Therapeutic Areas
Sponsors
Leads: Hospital Center Guillaume Régnier

This content was sourced from clinicaltrials.gov