Learn About Autoimmune Hepatitis
Autoimmune hepatitis is inflammation of the liver. It occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them.
Lupoid hepatitis; Chronic active hepatitis
This form of hepatitis is an autoimmune disease. The body's immune system cannot tell the difference between healthy body tissue and harmful, outside substances. The result is an immune response that destroys normal body tissues.
Liver inflammation, or hepatitis, may occur along with other autoimmune diseases. These include:
- Graves disease
- Inflammatory bowel disease
- Rheumatoid arthritis
- Scleroderma
- Sjögren syndrome
- Systemic lupus erythematosus
- Thyroiditis
- Type 1 diabetes
- Ulcerative colitis
Autoimmune hepatitis may occur in family members of people with autoimmune diseases. There may be a genetic cause.
This disease is most common in young girls and women.
Symptoms may include:
- Fatigue
- General discomfort, uneasiness, or ill feeling (malaise)
- Itching
- Loss of appetite
- Nausea or vomiting
- Joint pain
- Pale or clay-colored stools
- Dark urine
- Abdominal distention
Absence of menstruation (amenorrhea) may also be a symptom.
You may need prednisone or other corticosteroid medicines to help reduce the inflammation. Azathioprine and 6-mercaptopurine are drugs used to treat other autoimmune disorders. They have also been shown to help people with autoimmune hepatitis.
Some people may need a liver transplant.
Indiana University Health
IU Health Physicians Rare Liver Disease Program
Craig Lammert is a Gastroenterologist in Indianapolis, Indiana. Dr. Lammert has been practicing medicine for over 15 years and is rated as an Elite doctor by MediFind in the treatment of Autoimmune Hepatitis. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are Autoimmune Hepatitis, Hepatitis, Primary Biliary Cholangitis, and Sclerosing Cholangitis. He is licensed to treat patients in Georgia, Minnesota, and Indiana. Dr. Lammert is currently accepting new patients.
Internal Medicine
German Society For Internal Medicine
Ansgar Lohse is a Gastroenterologist and an Internal Medicine expert in Hamburg, Germany. Lohse is rated as an Elite expert by MediFind in the treatment of Autoimmune Hepatitis. They are also highly rated in 18 other conditions, according to our data. Their top areas of expertise are Autoimmune Hepatitis, Hepatitis, Hepatitis E, and Cirrhosis.
Children's Liver Disease Foundation
Gideon Hirschfield is in United Kingdom. Hirschfield is rated as an Elite expert by MediFind in the treatment of Autoimmune Hepatitis. He is also highly rated in 16 other conditions, according to our data. His top areas of expertise are Primary Biliary Cholangitis, Cholangitis, Sclerosing Cholangitis, and Autoimmune Hepatitis.
The outcome varies. Corticosteroid medicines may slow the progress of the disease. However, autoimmune hepatitis may advance to cirrhosis. This could require a liver transplant.
Complications may include:
- Cirrhosis
- Side effects from steroids and other medicines
- Hepatocellular carcinoma
- Liver failure
- Bleeding from varices
- Ascites
- Hepatic encephalopathy
Call your health care provider if you notice symptoms of autoimmune hepatitis.
In most cases, autoimmune hepatitis cannot be prevented. Knowing the risk factors may help you detect and treat the disease early.
Published Date : October 27, 2020
Published By : Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Czaja AJ. Autoimmune hepatitis.In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 90.
Pawlotsky J-M. Chronic viral and autoimmune hepatitis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 140.