Learn About Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

What is the definition of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy?

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited condition that affects many of the body's organs. It is one of many autoimmune diseases, which are disorders that occur when the immune system malfunctions and attacks the body's own tissues and organs by mistake.

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What are the causes of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy?

Mutations in the AIRE gene cause APECED. The AIRE gene provides instructions for making a protein called the autoimmune regulator. As its name suggests, this protein plays a critical role in regulating certain aspects of immune system function. Specifically, it helps the body distinguish its own proteins and cells from those of foreign invaders (such as bacteria, fungi, and viruses). This distinction is critical because to remain healthy, a person's immune system must be able to identify and destroy potentially harmful invaders while sparing the body's normal tissues.

How prevalent is Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy?

APECED occurs in about 1 in 90,000 to 200,000 people in most populations studied, which have been mainly in Europe. This condition occurs more frequently in certain populations, affecting about 1 in 9,000 to 25,000 people among Iranian Jews, Sardinians, and Finns.

Is Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy an inherited disorder?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Who are the top Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Local Doctors?
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Highly rated in
7
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University Of Tartu

Department Of Internal Medicine, Institute Of Clinical Medicine 
Tartu, EE 

Kai Kisand is in Tartu, Estonia. Kisand is rated as an Elite expert by MediFind in the treatment of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. They are also highly rated in 7 other conditions, according to our data. Their top areas of expertise are Autoimmune Polyglandular Syndrome Type 2, Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, Pyle Disease, and Type 1 Diabetes.

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21
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University Of Bergen

Bergen, NO 

Eystein Husebye is in Bergen, Norway. Husebye is rated as an Elite expert by MediFind in the treatment of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. They are also highly rated in 21 other conditions, according to our data. Their top areas of expertise are Addison's Disease, Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, Autoimmune Polyglandular Syndrome Type 2, and Acute Adrenal Crisis.

 
 
 
 
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Elite
Highly rated in
9
conditions

University Medical Center Of The Johannes Gutenberg University

Mainz, RP, DE 

George Kahaly is in Mainz, Germany. Kahaly is rated as an Elite expert by MediFind in the treatment of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. He is also highly rated in 9 other conditions, according to our data. His top areas of expertise are Graves Disease, Hyperthyroidism, Thyroid Eye Disease, and Autoimmune Polyglandular Syndrome Type 2.

What are the latest Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Clinical Trials?
Characterization of the Fungal Origins in the Autoimmune Polyendocrinopathy of Type 1 Compared With the Autoimmune Polyendocrinopathies of Type 2
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Who are the sources who wrote this article ?

Published Date:updated Last, May

Published By: National Institutes of Health

What are the Latest Advances for Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy?
Rituximab as Maintenance Therapy in Type 1 Autoimmune Pancreatitis: An Italian Experience.
Molecular and clinical characterization of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) in Iranian non-Jewish patients: report of two novel AIRE gene pathogenic variants.
Tired of the same old research?
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Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1).