Autoimmune Polyglandular Syndrome Type 2 Overview

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Learn About Autoimmune Polyglandular Syndrome Type 2

What is the definition of Autoimmune Polyglandular Syndrome Type 2?
Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. It is characterized by the presence of Addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. Affected individuals may also have problems with other endocrine glands and other common features include primary hypogonadism, myasthenia gravis, and celiac disease. Autoimmune polyglandular syndrome type 2 is diagnosed in adulthood. The cause of Autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. This condition occurs more often in women than men. Currently, there are no unique tests to detect APS-2, but testing for autoantibodies may be helpful in assessing disease risk, since the relevant autoantibodies (such as antibodies to thyroid peroxidase in autoimmune thyroid disease, or to glutamic acid decarboxylase in type 1 diabetes) are frequently detectable years before disease onset.
What are the alternative names for Autoimmune Polyglandular Syndrome Type 2?
  • Autoimmune polyglandular syndrome type 2
  • APS2
  • Autoimmune polyendocrine syndrome type 2
  • Autoimmune polyglandular syndrome type II
  • Diabetes mellitus, Addison's disease, myxedema
  • Multiple endocrine deficiency syndrome, type 2
  • PGA 2
  • PGA-II
  • Polyglandular autoimmune syndrome, type 2
  • Polyglandular deficiency syndrome type 2
  • Schmidt syndrome
  • Schmidt's syndrome
Who are the top Autoimmune Polyglandular Syndrome Type 2 Local Doctors?
Elite in Autoimmune Polyglandular Syndrome Type 2
Saila M. Laakso
Elite in Autoimmune Polyglandular Syndrome Type 2
Saila M. Laakso
Helsinki, FI 

Saila Laakso practices in Helsinki, Finland. Ms. Laakso is rated as an Elite expert by MediFind in the treatment of Autoimmune Polyglandular Syndrome Type 2. Her top areas of expertise are Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), Autoimmune Polyglandular Syndrome Type 2, Pyle Disease, and Addison's Disease.

Elite in Autoimmune Polyglandular Syndrome Type 2
Kai E. Kisand
Elite in Autoimmune Polyglandular Syndrome Type 2
Kai E. Kisand
Tartu, EE 

Kai Kisand practices in Tartu, Estonia. Kisand is rated as an Elite expert by MediFind in the treatment of Autoimmune Polyglandular Syndrome Type 2. Their top areas of expertise are Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), Autoimmune Polyglandular Syndrome Type 2, Pyle Disease, and Cerebral Hypoxia.

 
 
 
 
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Elite in Autoimmune Polyglandular Syndrome Type 2
Outi M. Makitie
Elite in Autoimmune Polyglandular Syndrome Type 2
Outi M. Makitie
Stockholm, AB, SE 

Outi Makitie practices in Stockholm, Sweden. Makitie is rated as an Elite expert by MediFind in the treatment of Autoimmune Polyglandular Syndrome Type 2. Their top areas of expertise are Cartilage-Hair Hypoplasia, Autoimmune Polyglandular Syndrome Type 2, Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), Osteogenesis Imperfecta, and Hormone Replacement Therapy (HRT).

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What are the latest Autoimmune Polyglandular Syndrome Type 2 Clinical Trials?
A Phase 2 Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis
A Phase 2 Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis
Enrollment Status: Recruiting
Publish Date: December 11, 2025
Intervention Type: Drug
Study Phase: Phase 2

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as Autoimmune polyendocrine syndrome type-1 (APS-1), is a disease that causes the immune system to attack parts of a person s body. In some people, APECED attacks the small intestine; this causes an illness called enteritis.

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The Natural History and Pathogenesis of Human Fungal Infections
The Natural History and Pathogenesis of Human Fungal Infections
Enrollment Status: Recruiting
Publish Date: December 08, 2025

Background: \- The immune system is made up of special cells, tissues, and organs that fight infections. Problems with this system may lead to frequent, severe, or unusual fungal infections. These infections are often difficult to treat. Researchers want to collect blood and tissue samples from people who have unusual, persistent or severe fungal infections or immune problems that increase the risk of these i...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center