Autonomic Neuropathy and Its Pathophysiology in Autoimmune Autonomic Neuropathies, Postural Orthostatic Tachycardia Syndrome and Ehlers Danlos Syndromes: Peripheral Autonomic Small Fiber Neuropathy or Central Autonomic Failure? Validation of the Malmö POTS Score and a Better Diagnosis of POTS in Patientes With Autnomic Failure (VaGeMAPS-3-step-Diag)
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
View:
• autonomic neuropathy
• Postural orthostatic tachycardia syndrome
• hypermobile or classical Ehlers Danlos syndromes
• in patients: diagnosis and clinical testing in our outpatient clinic
• German speaking
Locations
Other Locations
Germany
University clinic RWTH Aachen
RECRUITING
Aachen
Contact Information
Primary
Andrea Maier, physician
ans-ambulanz@ukaachen.de
+492418089600
Backup
Denver Igharo, student
ans-ambulanz@ukaachen.de
+492418089600
Time Frame
Start Date:2019-09-15
Estimated Completion Date:2029-09-15
Participants
Target number of participants:200
Treatments
Postural Orthostatic Tachycardia Syndrome
Patients with orthostatic intolerance because of Postural orthostatic tachycardia syndrome diagnosed in our outpatient clinic by tilt table examination.
Ehlers Danlos Syndrome
Patients with hypermobile or classical EDS who are already diagnosed including genetical testing for classical or vascular EDS and Marfan Syndromes
Patients who have an autoimmune autonomic neuropathy based on clinical diagnosis and antibody testing in our outpatient clinic. Cardial MIBG Scintigraphy should have been performed.
Healthy controls
Healthy controls with no documented cardiovascular or neurological disorders and no symtoms of autonomic failure/dizziness/fainting
others
Patients who have comorbidities as mast cell activation syndrome, chronic fatigue and/or Post COVID syndrome, based on clinical diagnosis in our outpatient clinic.