What is the definition of Autosomal Cleft Palate?

Autosomal dominant cleft palate is a common genetic condition present at birth in which an infant has an abnormal opening in the roof of the mouth. This condition can also be associated with a cleft lip or other birth defects. Autosomal dominant cleft palate is an inherited condition passed on by one of the parents.

What are the symptoms for Autosomal Cleft Palate?

Symptoms of a cleft palate include a split in the hard palate (roof of the mouth) that is present at birth. Some cleft palates may occur in the soft palate at the back of the mouth (submucous cleft palate) and are not identified until later. Symptoms of submucous cleft palate may include poor feeding, difficulty swallowing, and chronic ear infections.

What are the current treatments for Autosomal Cleft Palate?

Treatment for cleft palate is managed by a multidisciplinary care team of specialists and may include surgical cleft palate repair, reconstructive surgery, dental repair, antibiotics for ear infections, ear surgery, and speech therapy. Families that carry the autosomal dominant gene for cleft palate should also consider genetic counseling.
  • Condition: Vulvovagnial Candidiasis in First Trimester Pregnancy
  • Journal: BMJ (Clinical research ed.)
  • Treatment Used: Oral Fluconazole
  • Number of Patients: 0
  • Published —
This study examined the risk of congenital malformations associated with exposure to oral fluconazole at commonly used doses in the first trimester of pregnancy for the treatment of vulvovaginal candidiasis.
  • Condition: Partial Congenital Hypogonadotropic Hypogonadism (PCHH) or Complete Congenital Hypogonadotropic Hypogonadism (CCHH) in Chinese Patients
  • Journal: Asian journal of andrology
  • Treatment Used: Gonadotropin-Induced Spermatogenesis
  • Number of Patients: 122
  • Published —
This study compared the outcomes of gonadotropin-induced spermatogenesis (hormone-induced sperm production) on patients with partial congenital hypogonadotropic hypogonadism (PCHH) or complete congenital hypogonadotropic hypogonadism (CCHH).
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 1
  • Intervention Type: Drug
  • Participants: 60
  • Start Date: November 2011
Kisspeptin in the Evaluation of Delayed Puberty