Autosomal Dominant Hyper IgE Syndrome Symptoms, Doctors, Treatments, Advances & More

Learn About Autosomal Dominant Hyper IgE Syndrome

What is the definition of Autosomal Dominant Hyper IgE Syndrome?

Autosomal dominant hyper IgE syndrome (AD-HIES), formerly known as Job syndrome, affects several body systems including the immune system. AD-HIES is characterized by abnormally high levels of an immune system protein called immunoglobulin E (IgE) in the blood. Signs and symptoms may include recurrent infections (e.g., pneumonia, skin infections), eczema, and occasionally bone and tooth abnormalities. The eczema and skin infections may cause rashes, blisters, collections of pus (abscesses), open sores, and scaling of the skin. Some cases of AD-HIES are caused by genetic changes in the STAT3 gene. In other cases, the cause is unknown.

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What are the alternative names for Autosomal Dominant Hyper IgE Syndrome?

Autosomal dominant hyper IgE syndrome
AD hyperimmunoglobulin E syndrome
AD-HIES
HIES autosomal dominant
Hyper Ig E syndrome, autosomal dominant
Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant
Job syndrome autosomal dominant

Who are the top Autosomal Dominant Hyper IgE Syndrome Local Doctors?

Bodo Grimbacher

Elite

Highly rated in

conditions

University Of Freiburg

Royal Free Hospital,

London, ENG, GB

Bodo Grimbacher practices in London, United Kingdom. Grimbacher is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Hyper IgE Syndrome. They are also highly rated in 8 other conditions, according to our data. Their top areas of expertise are Common Variable Immune Deficiency, Hyper IGE Syndrome, Autosomal Dominant Hyper IgE Syndrome, Primary Immunodeficiency (PID), and Bone Marrow Transplant.

Andrew R. Gennery

Elite

Highly rated in

conditions

Great North Children's Hospital

Newcastle Upon Tyne, GB

Andrew Gennery practices in Newcastle Upon Tyne, United Kingdom. Gennery is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Hyper IgE Syndrome. He is also highly rated in 36 other conditions, according to our data. His top areas of expertise are Severe Combined Immunodeficiency (SCID), Primary Immunodeficiency (PID), Chronic Granulomatous Disease, Bone Marrow Transplant, and Heart Transplant.

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Dr. Talal A. Chatila

Pediatric Allergy and Immunology | Allergy and Immunology

Elite

Highly rated in

conditions

Pediatric Allergy and Immunology
Allergy and Immunology

Boston Childrens Hospital

300 Longwood Ave,

Boston, MA

Talal Chatila is a Pediatric Allergy and Immunologist and an Allergy and Immunologist in Boston, Massachusetts. Chatila has been practicing medicine for over 39 years and is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Hyper IgE Syndrome. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Autosomal Dominant Hyper IgE Syndrome, Hyper IGE Syndrome, Food Allergy, and Asthma. Chatila is currently accepting new patients.

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What are the latest Autosomal Dominant Hyper IgE Syndrome Clinical Trials?

Enrollment Status: Recruiting

Publish Date: February 08, 2023

Intervention Type: Procedure, Drug

Study Phase: Phase 2

Background: -DOCK8 deficiency is a genetic disorder that affects the immune system and can lead to severe recurrent infections and possible death from infections or certain types of cancers, including blood cancers. A stem cell transplant is a life-saving treatment for this condition. In this study we are evaluating the efficacy and safety of transplant from different donor sources for DOCK8 deficiency. The d...

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Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

Enrollment Status: Recruiting

Publish Date: February 03, 2023

Summary: The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder with skeletal, vascular, and connective tissue manifestations. Understanding how STAT3 mutations cause these diverse clinical manifestations is critical...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Autosomal Dominant Hyper IgE Syndrome?