Learn About Autosomal Dominant Hyper IgE Syndrome

What is the definition of Autosomal Dominant Hyper IgE Syndrome?
Autosomal dominant hyper IgE syndrome (AD-HIES), formerly known as Job syndrome, affects several body systems including the immune system. AD-HIES is characterized by abnormally high levels of an immune system protein called immunoglobulin E (IgE) in the blood. Signs and symptoms may include recurrent infections (e.g., pneumonia, skin infections), eczema, and occasionally bone and tooth abnormalities. The eczema and skin infections may cause rashes, blisters, collections of pus (abscesses), open sores, and scaling of the skin. Some cases of AD-HIES are caused by genetic changes in the STAT3 gene. In other cases, the cause is unknown.
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What are the alternative names for Autosomal Dominant Hyper IgE Syndrome?
  • Autosomal dominant hyper IgE syndrome
  • AD hyperimmunoglobulin E syndrome
  • AD-HIES
  • HIES autosomal dominant
  • Hyper Ig E syndrome, autosomal dominant
  • Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant
  • Job syndrome autosomal dominant
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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