Learn About Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE)

What is the definition of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE)?

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is an uncommon form of epilepsy that runs in families. This disorder causes seizures that usually occur at night (nocturnally) while an affected person is sleeping. Some people with ADNFLE also have seizures during the day.

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What are the causes of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE)?

Mutations in the CHRNA2, CHRNA4, and CHRNB2 genes can cause ADNFLE. These genes provide instructions for making different parts (subunits) of a larger molecule called a neuronal nicotinic acetylcholine receptor (nAChR). This receptor plays an important role in chemical signaling between nerve cells (neurons) in the brain.

How prevalent is Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE)?

ADNFLE appears to be an uncommon form of epilepsy; its prevalence is unknown. This condition has been reported in more than 100 families worldwide.

Is Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE) an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to raise the risk of developing epilepsy. About 70 percent of people who inherit a mutation in the CHRNA2, CHRNA4, or CHRNB2 gene will develop seizures. In most cases, an affected person has one affected parent and other relatives with the condition. Other cases are described as sporadic, which means an affected person has no family history of the disorder.

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What are the latest Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE) Clinical Trials?
A Non-Drug, Longitudinal, Prospective Natural History Study of Individuals With KCNT1-Related Epilepsy (K1Te)
Summary: The primary objective of the study is to characterize seizures in participants with KCNT1-related epilepsy. The secondary objectives are to characterize head growth, symptom severity, neurocognitive and social functions, adaptive behavior, sleep, quality of life, caregiver burden, and mood in participants with KCNT1-related epilepsy.
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Who are the sources who wrote this article ?

Published Date: April 01, 2009Published By: National Institutes of Health

What are the Latest Advances for Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE)?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.