Learn About Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

What is the definition of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy?

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is an uncommon form of epilepsy that runs in families. This disorder causes seizures that usually occur at night (nocturnally) while an affected person is sleeping. Some people with ADNFLE also have seizures during the day.

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What are the causes of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy?

Mutations in the CHRNA2, CHRNA4, and CHRNB2 genes can cause ADNFLE. These genes provide instructions for making different parts (subunits) of a larger molecule called a neuronal nicotinic acetylcholine receptor (nAChR). This receptor plays an important role in chemical signaling between nerve cells (neurons) in the brain.

How prevalent is Autosomal Dominant Nocturnal Frontal Lobe Epilepsy?

ADNFLE appears to be an uncommon form of epilepsy; its prevalence is unknown. This condition has been reported in more than 100 families worldwide.

Is Autosomal Dominant Nocturnal Frontal Lobe Epilepsy an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to raise the risk of developing epilepsy. About 70 percent of people who inherit a mutation in the CHRNA2, CHRNA4, or CHRNB2 gene will develop seizures. In most cases, an affected person has one affected parent and other relatives with the condition. Other cases are described as sporadic, which means an affected person has no family history of the disorder.

Who are the top Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Local Doctors?
Elite
Highly rated in
2
conditions

University Of Milano Bicocca

Milan, IT 

Andrea Becchetti is in Milan, Italy. Becchetti is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. She is also highly rated in 2 other conditions, according to our data. Her top areas of expertise are Autosomal Dominant Nocturnal Frontal Lobe Epilepsy, Partial Familial Epilepsy, Epilepsy, and Seizures.

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Highly rated in
7
conditions

Neurology Division, Geneva University Hospitals

Geneve, GE, CH 1211

Fabienne Picard is in Geneve, Switzerland. Picard is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. She is also highly rated in 7 other conditions, according to our data. Her top areas of expertise are Autosomal Dominant Nocturnal Frontal Lobe Epilepsy, Partial Familial Epilepsy, Epilepsy, and Seizures.

 
 
 
 
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Distinguished
Highly rated in
8
conditions
Neurology

University of California San Francisco Health System

Epilepsy Center

400 Parnassus Ave 
San Francisco, CA 94143

Robert Knowlton is a Neurologist in San Francisco, California. Dr. Knowlton has been practicing medicine for over 33 years and is rated as a Distinguished doctor by MediFind in the treatment of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Autosomal Dominant Nocturnal Frontal Lobe Epilepsy, Partial Seizure, Seizures, and Memory Loss. He is licensed to treat patients in Alabama. Dr. Knowlton is currently accepting new patients.

What are the latest Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Clinical Trials?
A Non-Drug, Longitudinal, Prospective Natural History Study of Individuals With KCNT1-Related Epilepsy (K1Te)
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Who are the sources who wrote this article ?

Published Date:updated Last, April

Published By: National Institutes of Health

What are the Latest Advances for Autosomal Dominant Nocturnal Frontal Lobe Epilepsy?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.