Learn About Autosomal Dominant Polycystic Kidney Disease

What is the definition of Autosomal Dominant Polycystic Kidney Disease?
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. ADPKD is a progressive disease and symptoms tend to get worse over time. The most common symptoms are kidney cysts, pain in the back and the sides and headaches. Other symptoms include liver and pancreatic cysts, urinary tract infections, abnormal heart valves, high blood pressure, kidney stones, and brain aneurysms. ADPKD is most often caused by changes in the PKD1 and PKD2 genes, and less often by changes in the GANAB and DNAJB11 genes. It is inherited in a dominant pattern. ADPKD is the most common inherited disorder of the kidneys.
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What are the alternative names for Autosomal Dominant Polycystic Kidney Disease?
  • Autosomal dominant polycystic kidney disease
  • ADPKD
  • Polycystic kidney disease, adult type
Who are the top Autosomal Dominant Polycystic Kidney Disease Local Doctors?
RP
Dr. Ronald D. Perrone
Nephrology
Elite
Highly rated in
4
conditions
Nephrology

Tufts Medical Center Health System

Tufts Medical Center

35 Kneeland St, 
Boston, MA 

Ronald Perrone is a Nephrologist in Boston, Massachusetts. Perrone has been practicing medicine for over 48 years and is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Polycystic Kidney Disease. He is also highly rated in 4 other conditions, according to our data. His top areas of expertise are Autosomal Dominant Polycystic Kidney Disease, Polycystic Kidney Disease, Chronic Kidney Disease, Autosomal Recessive Polycystic Kidney Disease, and Kidney Transplant. Perrone is currently accepting new patients.

AC
Dr. Arlene B. Chapman
Nephrology
Elite
Highly rated in
6
conditions
Nephrology

UChicago Medicine

UChicago Medicine River East

355 E Grand Ave, 
Chicago, IL 

Arlene Chapman is a Nephrologist in Chicago, Illinois. Chapman has been practicing medicine for over 40 years and is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Polycystic Kidney Disease. She is also highly rated in 6 other conditions, according to our data. Her top areas of expertise are Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease, Chronic Kidney Disease, Alport Syndrome, and Kidney Transplant. Chapman is currently accepting new patients.

 
 
 
 
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MC
Dr. Michel B. Chonchol
Nephrology
Elite
Highly rated in
10
conditions
Nephrology

UCHealth

UCHealth University Of Colorado Hospital

1635 Aurora Ct, 
Aurora, CO 

Michel Chonchol is a Nephrologist in Aurora, Colorado. Chonchol has been practicing medicine for over 29 years and is rated as an Elite expert by MediFind in the treatment of Autosomal Dominant Polycystic Kidney Disease. He is also highly rated in 10 other conditions, according to our data. His top areas of expertise are Autosomal Dominant Polycystic Kidney Disease, Polycystic Kidney Disease, Chronic Kidney Disease, Hormone Replacement Therapy (HRT), and Kidney Transplant. Chonchol is currently accepting new patients.

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What are the latest Autosomal Dominant Polycystic Kidney Disease Clinical Trials?
Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease
Who is this study for: Adult patients with Autosomal Dominant Polycystic Kidney Disease
Enrollment Status: Enrolling by invitation
Publish Date: February 14, 2023
Intervention Type: Drug
Study Drugs: PravastatinSodium Citrate
Study Phase: Phase 2

Summary: This is an one-year open-label study to determine treatment efficacy and feasibility of a trial that uses open-label interventions in ADPKD patients.

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A Phase 1b, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study in Patients With Autosomal Dominant Polycystic Kidney Disease to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RGLS8429
Enrollment Status: Recruiting
Publish Date: February 14, 2023
Intervention Type: Drug
Study Phase: Phase 1

Summary: Primary Objectives To assess the safety and tolerability of RGLS8429 To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) To characterize the pharmacokinetic (PK) properties of RGLS8429 To assess the impact of RGLS8429 on renal function

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Autosomal Dominant Polycystic Kidney Disease?
Bilateral laparoscopic nephrectomy for polycystic kidney disease.
Condition: Polycystic Kidney Disease
Journal: Urologiia (Moscow, Russia : 1999)
Treatment Used: Bilateral Laparoscopic Nephrectomy
Number of Patients: 1
Published: September 13, 2022
Romosozumab successfully regulated progressive osteoporosis in a patient with autosomal dominant polycystic kidney disease undergoing hemodialysis.
Condition: Osteoporosis/Chronic Kidney Disease (CKD)
Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Treatment Used: Romosozumab
Number of Patients: 1
Published: August 18, 2022
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Simultaneous Robotic-Assisted Bilateral Native Nephrectomy and Kidney Transplantation for Autosomal Dominant Polycystic Kidney Disease in Recipients With High Body Mass Index: Report of 2 Cases.
Condition: Autosomal Dominant Polycystic Kidney Disease in Recipients With High Body Mass Index
Journal: Transplantation proceedings
Treatment Used: Simultaneous Robotic-Assisted Bilateral Native Nephrectomy and Kidney Transplantation
Number of Patients: 2
Published: July 31, 2022
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