Assessment of Janus Kinase 2 Expression in Patients With Androgenic Alopecia and Its Modulation by Topical Minoxidil Therapy.
Androgenetic alopecia is a common form of progressive hair loss. This prospective single-arm pre-post interventional study aims to assess tissue Janus Kinase 2 (JAK2) expression in patients with androgenetic alopecia by comparing balding and non-balding scalp at baseline, and to evaluate changes in JAK2 expression in balding scalp after 3 months of topical minoxidil 5% therapy. Clinical response will be assessed using standardized trichoscopic parameters.
• Male adults aged 18 to 50 years with androgenetic alopecia.
• Mild to moderate disease severity, defined as Hamilton-Norwood scale II to V.
• Patients who are treatment-naive or willing to undergo an adequate washout period for prior hair loss therapies of at least 1 month.
• Willing and able to provide written informed consent.