Condition 101 About Benign Essential Blepharospasm

What is the definition of Benign Essential Blepharospasm?

Benign essential blepharospasm (BEB) is a progressive neurological disorder characterized by abnormal blinking or spasms of the eyelids. It is a form of dystonia, a group of movement disorders involving uncontrolled tensing of the muscles (contractions), rhythmic shaking (tremors), and other involuntary movements. BEB occurs in both men and women, although it is especially common in middle-aged women.

Initial symptoms include an increased frequency of blinking, dry eyes, and eye irritation. As the condition progresses, spasms of the muscles surrounding the eyes cause involuntary winking or squinting and increasing difficulty keeping eyes open, which can lead to vision impairment. In more than half of all people with BEB, the symptoms affect other facial muscles and muscles in other areas of the body. When people with BEB also experience involuntary muscle spasms affecting the tongue and jaw, this is known as Meige syndrome. The cause of BEB is unknown; however, some cases appear to run through families. Although there is no cure for BEB, symptoms can be treated using various methods including botulinum toxin injections. 

What are the alternative names for Benign Essential Blepharospasm?

  • BEB
  • OBSOLETE: Benign essential blepharospasm
  • Primary blepharospasm
  • Blepharospasm

Latest Advances On Benign Essential Blepharospasm

  • Condition: Meige Syndrome-Like Blepharospasm caused by Ingestion of Allopurinol
  • Journal: Pakistan journal of pharmaceutical sciences
  • Treatment Used: Botulinum Toxin
  • Number of Patients: 1
  • Published —
This case report describes a patient with Meige syndrome-like blepharospasm that was caused by ingestion of allopurinol.
  • Condition: Parkinson's Disease
  • Journal: Toxins
  • Treatment Used: Botulinum Neurotoxin
  • Number of Patients: NULL
  • Published —
The study researched the outcomes of botulinum neurotoxin for treating Parkinson's disease.

Clinical Trials For Benign Essential Blepharospasm

Clinical Trial
  • Status: Enrolling by invitation
  • Phase: Phase 2/Phase 3
  • Intervention Type: Drug
  • Participants: 12
  • Start Date: May 20, 2020
Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm - a Prospective Double-masked Cross-over Study
Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Drug, Other, Diagnostic Test
  • Participants: 40
  • Start Date: October 23, 2019
Analyse de la Marche de Patients Atteints de Dystonie Focale Avant et après Traitement Par Toxine Botulique