What is the definition of Benign Rolandic Epilepsy?

Benign rolandic epilepsy (BRE) is the most common form of childhood epilepsy. It is referred to as "benign" because most children outgrow the condition by puberty. This form of epilepsy is characterized by seizures involving a part of the brain called the rolandic area. These seizures typically begin between the ages of 3 and 12 years and occur during the nighttime. Other features of BRE include headaches or migraines and behavioral and/or learning differences. BRE is thought to be a genetic disorder because most affected individuals have a family history of epilepsy. Treatment for BRE may depend on the symptoms and severity in each person. Because BRE resolves on its own before adulthood, many children with BRE who have infrequent seizures that only occur at night do not take anti-epileptic drugs (AEDs). However, there have been studies suggesting that BRE may cause lasting cognitive or behavioral problems in some people. Medication is more likely to be recommended in children with frequent or daytime seizures, cognitive impairment, or a learning disorder. Each family must consult with their physician(s) and make their own decision about whether to treat BRE.

What are the alternative names for Benign Rolandic Epilepsy?

  • Benign rolandic epilepsy of childhood (BREC)
  • Benign epilepsy with centro-temporal spikes (BECTS)
  • Benign epilepsy of childhood with centrotemporal spikes (BECCT)

What are the causes for Benign Rolandic Epilepsy?

BRE is thought to be a genetic disorder. Studies suggest that certain regions on chromosome 11 (11p13) and chromosome 15 (15q14) may be involved in BRE, but a specific gene has not been identified.

What are the symptoms for Benign Rolandic Epilepsy?

BRE typically begins between the ages of 3 and 13 years with nighttime seizures. The episodes usually begin with twitching and stiffness in the face, that often wakes up the individual. There may be a tingling feeling on one side of the mouth that involves the tongue, lips, gums and inside of the cheek. The seizure can also involve the throat, which may make speech unclear and difficult to understand. Occasionally, both sides of the body may be affected, which can lead to stiffness and jerking movements of the arms and legs, and loss of consciousness. Loss of bladder control (incontinence) may also occur.

Some individuals with BRE experience headaches or migraines, learning difficulties, and behavioral problems during the period of time that they have seizures. In many children, once seizures stop and brain activity returns to normal, these issues resolve. However, there have been studies suggesting that cognitive or behavioral problems may persist in some people. More studies regarding whether there is an increased chance of long-term impairments in those with BRE are needed.

What are the current treatments for Benign Rolandic Epilepsy?

Treatment for BRE may depend on the symptoms and severity in each person. In general, BRE typically does not require intensive therapy. Because seizures may be infrequent and usually occur at night, and because of the potential side affects of anti-epileptic drugs, many children with BRE do not take medication. However, emerging data on neuropsychological problems in people with BRE suggests that the syndrome may not be entirely without long-term effects. A recently recognized concern in children with BRE is a higher incidence of neuropsychological deficits. Each family must consult with their physician(s) and make their own decision about whether they are more comfortable treating or not treating BRE. The need for medication is generally bigger if a child has frequent seizures, daytime seizures, cognitive problems, or a learning disorder.

When BRE is treated, medications may include AEDs such as carbamazepine, gabapentin, levetiracetam, or others. Most children with BRE respond to a low dose of a single drug, but some have seizures that are more drug-resistant, requiring higher doses or more than one drug.
Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Other
  • Participants: 100
  • Start Date: January 16, 2021
Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy
Clinical Trial
  • Status: Enrolling by invitation
  • Phase: N/A
  • Intervention Type: Device
  • Participants: 40
  • Start Date: October 28, 2020
Impact of Repetitive Transcranial Magnetic Stimulation (TMS) on Spike Frequency and Brain Connectivity in Children With Benign Epilepsy With Centrotemporal Spike (BECTS)