Learn About Beriberi

What is the definition of Beriberi?

Beriberi is a disease in which the body does not have enough thiamine (vitamin B1).

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What are the alternative names for Beriberi?

Thiamine deficiency; Vitamin B1 deficiency

What are the causes of Beriberi?

There are two major types of beriberi:

  • Wet beriberi: Affects the cardiovascular system.
  • Dry beriberi and Wernicke-Korsakoff syndrome: Affects the nervous system.

Beriberi is rare in the United States. This is because most foods are now vitamin enriched. If you eat a normal, healthy diet, you should get enough thiamine. Today, beriberi occurs mostly in people who abuse alcohol. Drinking heavily can lead to poor nutrition. Excess alcohol makes it harder for the body to absorb and store vitamin B1.

In rare cases, beriberi can be genetic. This condition is passed down through families. People with this condition lose the ability to absorb thiamine from foods. This can happen slowly over time. The symptoms occur when the person is an adult. However, this diagnosis is often missed. This is because health care providers may not consider beriberi in nonalcoholics.

Beriberi can occur in infants when they are:

  • Breastfed and the mother's body is lacking in thiamine
  • Fed unusual formulas that don't have enough thiamine

Some medical treatments that can raise your risk of beriberi are:

  • Getting dialysis
  • Taking high doses of diuretics (water pills)
What are the symptoms of Beriberi?

Symptoms of dry beriberi include:

  • Difficulty walking
  • Loss of feeling (sensation) in hands and feet
  • Loss of muscle function or paralysis of the lower legs
  • Mental confusion/speech difficulties
  • Pain
  • Strange eye movements (nystagmus)
  • Tingling
  • Vomiting

Symptoms of wet beriberi include:

  • Awakening at night short of breath
  • Increased heart rate
  • Shortness of breath with activity
  • Swelling of the lower legs
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What are the current treatments for Beriberi?

The goal of treatment is to replace the thiamine your body is lacking. This is done with thiamine supplements. Thiamine supplements are given through a shot (injection) or taken by mouth.

Your provider may also suggest other types of vitamins.

Blood tests may be repeated after the treatment is started. These tests will show how well you are responding to the medicine.

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What is the outlook (prognosis) for Beriberi?

Untreated, beriberi can be fatal. With treatment, symptoms usually improve quickly.

Heart damage is usually reversible. A full recovery is expected in these cases. However, if acute heart failure has already occurred, the outlook is poor.

Nervous system damage is also reversible, if caught early. If it is not caught early, some symptoms (such as memory loss) may remain, even with treatment.

If a person with Wernicke encephalopathy receives thiamine replacement, language problems, unusual eye movements, and walking difficulties may go away. However, Korsakoff syndrome (or Korsakoff psychosis) tends to develop as Wernicke symptoms go away.

What are the possible complications of Beriberi?

Complications may include:

  • Coma
  • Congestive heart failure
  • Death
  • Psychosis
When should I contact a medical professional for Beriberi?

Beriberi is extremely rare in the United States. However, call your provider if:

  • You feel your family's diet is inadequate or poorly balanced
  • You or your children have any symptoms of beriberi
How do I prevent Beriberi?

Eating a proper diet that is rich in vitamins will prevent beriberi. Nursing mothers should make sure that their diet contains all vitamins. If your infant is not breastfed, make sure that the infant formula contains thiamine.

If you drink heavily, try to cut down or quit. Also, take B vitamins to make sure your body is properly absorbing and storing thiamine.

What are the latest Beriberi Clinical Trials?
Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Congenital Heart Disease Surgery With Cardiopulmonary Bypass Procedure and Oral Thyroid Supplementation

Summary: This is a randomized, double-blind, controlled trial design. It was conducted with a main purpose of evaluating the effect of thiamine supplementation on serum lactate and lactate-pyruvate ratio after surgery as direct indicators of tissue perfusion and indirect markers of energy substrate availability for effective mitochondrial function and intubation time as clinical outcome.

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Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans

Summary: Thiamine micronutrient deficiency (TD) can cause a variety of non-specific symptoms and leads to several thiamine deficiency disorders such as heart failure, polyneuropathy, Wernicke's Encephalopathy and generalized weakness and debility. Symptoms are often vague and non-specific such as fatigue, leg swelling, imbalance, confusion, mood disorders, gastrointestinal upset, and weakness. Hospitalized...

What are the Latest Advances for Beriberi?
Identification of Wernicke Encephalopathy in a Patient Presenting With Altered Mental Status and Dehydration.
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Who are the sources who wrote this article ?

Published Date: August 13, 2020
Published By: Linda J. Vorvick, MD, Clinical Associate Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Koppel BS. Nutritional and alcohol-related neurologic disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 388.

Sachdev HPS, Shah D. Vitamin B complex deficiency and excess. In: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 62.

So YT. Deficiency diseases of the nervous system. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 85.