Enhancing Rehabilitation for Veterans With Serious Mental Illness Via Biomarker-Informed Cognitive Training

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chronic functional disability, and impaired outcomes, causing a significant strain on support networks and the VA healthcare system. This study aims to introduce an innovative mental health therapy, Targeted Cognitive Training (TCT), to Veterans struggling with serious mental illnesses (SMI). TCT works to improve basic sensory information processing and, ultimately, clinical, cognitive, and psychosocial functioning. By using EEG biomarkers to identify Veterans with SMI receiving care within VA Psychosocial Rehabilitation and Recovery Centers who are most likely to benefit from this treatment, and by understanding how best to implement this therapy, the investigators hope to enhance care and improve life quality for Veterans with SMI.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Veterans with SMI (e.g., schizophrenia, schizoaffective disorder, bipolar disorder, PTSD) being treated at PRRCs or co-located rehabilitative services.

• Age 18 and 75 years.

• Fluency in spoken and written English.

• Ability to detect 1000 Hz tones binaurally at a 40-dB sound pressure level.

• Ability to see with an acuity of 20/40 with both eyes tested together (corrected if applicable) by a standard printed Snellen eye chart reading card.

Locations
United States
California
VA San Diego Healthcare System, San Diego, CA
RECRUITING
San Diego
Contact Information
Primary
Joyce Sprock, BS
joyce.sprock@va.gov
(858) 552-8585
Backup
Abigail A Mack
abigail.mack@va.gov
(858) 642-6492
Time Frame
Start Date: 2025-02-25
Estimated Completion Date: 2028-10-31
Participants
Target number of participants: 80
Treatments
Active_comparator: TCT + TAU
Subjects will complete 30 hours of Targeted Cognitive Training (TCT) in addition to their Treatment as Usual (TAU)
No_intervention: TAU
Subjects will participate in their standard Treatment as Usual (TAU) PRRC program
Sponsors
Collaborators: University of California, San Diego
Leads: VA Office of Research and Development

This content was sourced from clinicaltrials.gov