Multi-parameter Magnetic Resonance Imaging for Early Evaluation of the Efficacy of Neoadjuvant Chemotherapy With Modified GC Regimen for Urothelial Carcinoma
Who is this study for? Patients with Muscle Invasive Bladder Cancer
Status: Recruiting
Location: See location...
Intervention Type: Drug, Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Purpose：To evaluate whether immediate multiparametric MRI evaluate the sensitivity of modified neoadjuvant chemotherapy early in patient with muscle invasive bladder cancer（MIBC）. Rationale：Multiparametric MRI may help detect the early changes of bladder cancer receiving neoadjuvant chemotherapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Pathologically confirmed primary or recurrent bladder cancer.
• Planned to undergo transurethral resection of bladder tumor (TURBT) or modified GC regimen neoadjuvant chemotherapy plus radical total cystectomy.
• 18 years old and older.
• Willing to give valid written informed consent.
• No contraindications to the MRI(magnetic resonance imaging) and MRI contrast agent.
Locations
Other Locations
China
The first affiliated hospital of Nanjing Medical University
RECRUITING
Nanjing
Contact Information
Primary
Yuan Baorui
yuanbr960720@163.com
+86 18351998926
Backup
Lv Qiang
doctorlvqiang@sina.com
+86 13505196501
Time Frame
Start Date: 2018-01-01
Estimated Completion Date: 2026-06
Participants
Target number of participants: 100
Treatments
Experimental: Experimental: Chemotherapy + mpMRI + surgery
Baseline mpMRI /Neoadjuvant chemotherapy /Immediate mpMRI /Cystectomy and Lymphadenectomy / Postoperative pathology~Drug: Chemotherapy Procedure: Immediate Multiparametric MRI Procedure: Cystectomy and Lymphadenectomy
Experimental: Experimental: Chemotherapy + surgery
Baseline mpMRI /Neoadjuvant chemotherapy /Cystectomy and Lymphadenectomy / Postoperative pathology~Drug: Chemotherapy Procedure: Cystectomy and Lymphadenectomy
Related Therapeutic Areas
Sponsors
Leads: The First Affiliated Hospital with Nanjing Medical University