Condition 101 About Blood Clots

What is the definition of Blood Clots?

Blood clots are clumps that occur when blood hardens from a liquid to a solid.

  • A blood clot that forms inside one of your veins or arteries is called a thrombus. A thrombus may also form in your heart.
  • A thrombus that breaks loose and travels from one location in the body to another is called an embolus.

A thrombus or embolus can partly or completely block the flow of blood in a blood vessel.

  • A blockage in an artery may prevent oxygen from reaching the tissues in that area. This is called ischemia. If ischemia is not treated promptly, it can lead to tissue damage or death.
  • A blockage in the vein will often cause fluid buildup and swelling.

What are the alternative names for Blood Clots?

Clot; Emboli; Thrombi; Thromboembolus; Hypercoagulable state

What are the causes for Blood Clots?

Situations in which a blood clot is more likely to form in veins include:

  • Being on long-term bed rest
  • Sitting for long periods, such as in a plane or car
  • During and after pregnancy
  • Taking birth control pills or estrogen hormones (especially in women who smoke)
  • Long-term use of an intravenous catheter
  • After surgery

Blood clots are also more likely to form after an injury. People with cancer, obesity, and liver or kidney disease are also prone to blood clots.

Smoking also increases the risk of forming blood clots.

Conditions that are passed down through families (inherited) may make you more likely to form abnormal blood clots. Inherited conditions that affect clotting are:

  • Factor V Leiden mutation
  • Prothrombin G20210A mutation

Other rare conditions, such as protein C, protein S, and antithrombin III deficiencies.

A blood clot may block an artery or vein in the heart, affecting the:

  • Heart (angina or a heart attack)
  • Intestines (mesenteric ischemia or mesenteric venous thrombosis)
  • Kidneys (renal vein thrombosis)
  • Leg or arm arteries
  • Legs (deep vein thrombosis)
  • Lungs (pulmonary embolism)
  • Neck or brain (stroke)
Thrombus
Deep

REFERENCES

Anderson JA, Hogg KE, Weitz JI. Hypercoagulable states. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 140.

Schafer AI. Approach to the patient with bleeding and thrombosis: hypercoagulable states. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 162.

Top Global Doctors For Blood Clots

FP
Elite
Flora Peyvandi
IT
GC
Elite
Giancarlo Castaman
Florence, IT
ES
Elite
Elena M. Santagostino
Milan, IT
JO
Elite
Johannes Oldenburg
Bonn, NW, DE
PC
Elite
Pratima C. Chowdary
London, ENG, GB

Latest Advances On Blood Clots

  • Condition: Hemophilia
  • Journal: Frontiers in immunology
  • Treatment Used: Plasma-Derived vs. Recombinant Factor VIII Products
  • Number of Patients: 0
  • Published —
This article discusses immune responses to plasma-derived versus recombinant factor VIII products in patients with hemophilia.
  • Condition: Spinal Epidural Hematoma with Hemophilia A
  • Journal: The Journal of international medical research
  • Treatment Used: Conservative Therapy with High-Titer VIII Inhibitors
  • Number of Patients: 1
  • Published —
This case report describes a patient with hemophilia A that experienced a spinal epidural hematoma.

Clinical Trials For Blood Clots

Clinical Trial
  • Status: Not yet recruiting
  • Intervention Type: Drug
  • Participants: 50
  • Start Date: June 30, 2021
Observational Study Evaluating Long-term Safety of Real-world Treatment With Damoctocog Alfa Pegol in Previously Treated Patients With Hemophilia A