Development of a Device for Evaluating Primary Hemostasis Under Whole Blood Flow Conditions

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Biological
Study Type: Observational
SUMMARY

Currently, the exploration of primary hemostasis (a physiological phenomenon used to stop bleeding) is imperfect because it is based on targeted tests for platelets or von Willebrand factor, without taking into account blood flow and other blood cells (red and white blood cells). Tests for whole blood and flow conditions exist, but there is currently no test that comes close to actual physiological conditions. An exploration of whole blood haemostasis in a device that is similar to a blood vessel and at different flow conditions (venous and arterial) could help to better identify the risk of bleeding in predisposed patients (von Willebrand factor deficiency, antiplatelet therapy). The objective of the study is to evaluate the performance of this new hemostasis test in whole blood and under flow conditions. Participation in the study is ad hoc and is limited to adding a maximum of 4 citrated tubes (20 mL or the equivalent of 4 teaspoons) and 1 EDTA tube (5mL) to a routine blood sample (for patients) or during blood donation (for controls).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• person who has given oral consent

• adult

• blood donor at EFS Bourgogne Franche-Comté

• or patient with von Willebrand disease or major constitutional thrombopathy followed by the Resource and Competence Centre (CRC) - Constitutional Hemorrhagic Diseases of Dijon or Besançon

• or patient on antiplatelet drugs consulting for thrombosis at the Dijon Bourgogne or Besançon Hospital

Locations
Other Locations
France
CHU de Besançon
RECRUITING
Besançon
CHU Dijon Bourgogne
RECRUITING
Dijon
Contact Information
Primary
Emmanuel De Maistre
emmanuel.demaistre@chu-dijon.fr
03 81 61 56 15
Time Frame
Start Date: 2019-05-06
Estimated Completion Date: 2026-05
Participants
Target number of participants: 200
Treatments
Patients
Patients with von Willebrand disease or major constitutional thrombopathy or patients on antiplatelet drugs
Controls
Blood donors at the French blood establishment in Burgundy Franche-Comté
Sponsors
Leads: Centre Hospitalier Universitaire Dijon

This content was sourced from clinicaltrials.gov