Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms
The purpose of the bCAN study is to create a prospective collection of multimodal data and human samples, linked to the French Intracranial Aneurysm Registry (FRAN). The aim of bCAN is to enable risk stratification of ruptured ICAs by redefining intracranial aneurysm disease. The description of genotypically and phenotypically specific subgroups of cases will pave the way for improved patient management based on new diagnostic/prognostic strategies among AIC carriers, either in a familial context, or at the level of the general population.
• Any adult patient consulting for a definite and typical bifurcation AIC authenticated on MRI and/or cerebral arteriography
• Aneurysm discovered less than a year ago, with initial imaging (MRI and/or CTA and DSA) available
• Written consent obtained for study participation
• Patient covered by a social security plan
• Index case: Any adult patient consulting for a definite and typical bifurcation ICA presenting at least one other case with ICA related (child, parent, brother, sister) detected by MRI with at least one Time of Flight (TOF) sequence.
• Family relatives: children, parents, brothers, sisters, of legal age, of patients with a family history of definite, typical bifurcation AIC (≥ 4 affected), Screening to be performed using MRI with at least a Time of Flight (TOF) sequence.
• Written consent to participate in the study
• Patient and relatives covered by a social security plan