Localized Mammary Alcohol Metabolism as a Mechanism Linking Low-Level Alcohol Intake to Breast Cancer Risk
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Alcohol consumption, even at low levels, has been associated with increased breast cancer risk, but the biological mechanisms underlying this relationship remain unclear. This study will examine whether breast tissue may locally metabolize alcohol by measuring alcohol-related compounds in paired blood and breast milk samples from lactating women. The findings may help clarify alcohol-related biological pathways relevant to breast cancer risk and improve risk communication.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 21
Maximum Age: 45
Healthy Volunteers: t
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‣ All aims
• Drink alcohol (at least one alcoholic drink during lactation of a lactating female)
‣ For aims 1 and 2
⁃ Nursing a 2- to 5-month-old infant
⁃ Experienced with a breast pump
Locations
United States
Illinois
Bevier Hall; University of Illinois at Urbana Champaign
RECRUITING
Urbana
Contact Information
Primary
Marta Y Pepino de Gruev, Ph D
ypepino@illinois.edu
217-300-2374
Time Frame
Start Date: 2026-09-03
Estimated Completion Date: 2032-03-01
Participants
Target number of participants: 50
Treatments
Experimental: Arm 1: lactating women dose response
Lactating women who will drink \~0, 1 or 2 standard drinks of alcohol
Experimental: Arm 2: timing of pumping
Lactating women will pump at two different times from alcohol drinking and at one of these times after placebo drinking
Other: Aim 3: non-lactating control women
Non-lactating women of similar age, BMI, and alcohol consumption characteristics will drink a similar dose of alcohol as lactating women for the assessment of systemic alcohol-related measurements. This group will serve as a comparison group for interpreting alcohol-related measurements in lactating participants.
Related Therapeutic Areas
Sponsors
Leads: University of Illinois at Urbana-Champaign