Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 day
Maximum Age: 1
Healthy Volunteers: f
View:

• Infants \<12 months

• With bronchiolitis during RSV epidemic season

• No chronic illness

• No bronchiolitis medical history

• Signed consent from parents or legal guardians

Locations
Other Locations
France
APHP, Antoine Béclère Hospital
RECRUITING
Clamart
AP-HP,Raymond Poincaré Hospital
RECRUITING
Garches
Réanimation médico-chirurgicale Necker
RECRUITING
Paris
Contact Information
Primary
Etienne BIZOT, Doctor
etienne.bizot@aphp.fr
33145374618
Time Frame
Start Date: 2024-12-06
Estimated Completion Date: 2026-04
Participants
Target number of participants: 120
Treatments
Severe bronchiolitis
venous blood samples. Buccal, nasopharyngeal and rectal swabs
Non-hospitalized bronchiolitis
Capillary blood samples. Buccal, nasopharyngeal and rectal swabs
Bronchiolitis ihospitalized in ICU
Capillary blood samples. Buccal, nasopharyngeal and rectal swabs
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris
Collaborators: Infectious Diseases Models for Innovative Therapies center

This content was sourced from clinicaltrials.gov