For anyone who has experienced bronchitis, the sensation is unmistakable: a deep, rattling cough that seems to linger for weeks, often accompanied by chest tightness and profound fatigue. Whether it is a short-term bout following a cold or a chronic condition requiring ongoing management, bronchitis disrupts sleep, work, and daily energy levels. The persistent coughing can leave muscles sore and make simple tasks feel exhausting.

Treatment is essential to relieve this discomfort, help clear mucus from the airways, and allow the body to rest and recover. While acute bronchitis often improves on its own with time, managing the symptoms makes the recovery process much more bearable. It is critical to distinguish between acute bronchitis (usually temporary and viral) and chronic bronchitis (a long-term condition often linked to smoking or environmental irritants). Medication plans vary significantly between these two types, depending on whether the goal is short-term symptom relief or long-term disease management (National Heart, Lung, and Blood Institute, 2022).

Overview of treatment options for Bronchitis

The approach to treating bronchitis depends entirely on whether the condition is acute or chronic. For acute bronchitis, which is almost always caused by a virus, the primary goal is supportive care, managing the cough, fever, and pain while the immune system fights the infection. Medications here target symptoms, not the underlying virus.

For chronic bronchitis, which is a form of chronic obstructive pulmonary disease (COPD), the goal is to reduce inflammation, open the airways, and prevent flare-ups. This requires a more complex, often daily, medication regimen. In both cases, lifestyle measures like hydration and avoiding smoke are foundational, but pharmacological treatments provide the necessary relief to function. Clinical experience suggests that antibiotics are frequently requested but rarely necessary for acute cases, as they do not kill viruses.

Medications used for Bronchitis

For acute bronchitis, over-the-counter medications are the first line of defense. Expectorants, such as guaifenesin, are commonly used to thin mucus, making it easier to cough up. Conversely, cough suppressants like dextromethorphan help block the cough reflex to allow for sleep, though doctors often recommend letting a “productive” cough do its job during the day. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin, as well as acetaminophen, are used to lower fever and relieve chest soreness.

If wheezing or difficulty breathing is present, doctors may prescribe a short-acting bronchodilator. Albuterol is a well-known example in this class, used temporarily to open the airways.

For chronic bronchitis, treatment is more aggressive. Long-acting bronchodilators (both beta-agonists and anticholinergics) are used daily to keep airways open. Inhaled corticosteroids, such as fluticasone or budesonide, are often added to reduce chronic inflammation in the bronchial tubes. In severe cases, phosphodiesterase-4 inhibitors like roflumilast may be prescribed to decrease flare-ups.

Antibiotics, such as azithromycin or doxycycline, are generally reserved for cases where there is a confirmed bacterial infection or for patients with chronic lung conditions experiencing a severe exacerbation (Centers for Disease Control and Prevention, 2021).

How these medications work

Expectorants work by increasing the water content of the mucus, thinning it out so it moves more easily through the airways. Suppressants act on the part of the brain that controls the coughing reflex, essentially “muting” the urge to cough.

Bronchodilators relax the smooth muscles wrapped around the airways. When these muscles tighten (bronchospasm), breathing becomes hard. These drugs release that tension, widening the tubes to let more air pass through. Corticosteroids work by suppressing the immune system’s inflammatory response, reducing the swelling and mucus production inside the bronchial tubes that characterize chronic bronchitis (Mayo Clinic, 2023).

Side effects and safety considerations

Cough/cold medicines can cause drowsiness/dizziness. Expectorants are safe but require ample water to be effective. Bronchodilators, like albuterol, may cause temporary increased heart rate, jitteriness, or shaking hands.

Inhaled corticosteroids can cause oral thrush if the mouth isn’t rinsed afterward. Long-term use of oral steroids/strong anti-inflammatories risks stomach/bone issues. Avoid unnecessary antibiotics, as overuse causes resistance and digestive problems. Seek immediate care for unresolving shortness of breath, high fever, or blood in mucus. Since everyone’s experience with the condition and its treatments can vary, working closely with a qualified healthcare provider helps ensure safe and effective care.

References

  1. Centers for Disease Control and Prevention. https://www.cdc.gov
  2. Mayo Clinic. https://www.mayoclinic.org
  3. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov
  4. American Lung Association. https://www.lung.org

Medications for Bronchitis

These are drugs that have been approved by the US Food and Drug Administration (FDA), meaning they have been determined to be safe and effective for use in Bronchitis.

Found 14 Approved Drugs for Bronchitis

Azithromycin

Brand Names
Azasite, Zithromax

Azithromycin

Brand Names
Azasite, Zithromax
Azithromycin for oral suspension USP is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Recommended dosages and durations of therapy in adult and pediatric patient populations vary in these indications.

Trimethoprim

Brand Names
Sulfamethox-TMP, Sulfatrim, Sulfamethoxazole, Bactrim, Sulfameth

Trimethoprim

Brand Names
Sulfamethox-TMP, Sulfatrim, Sulfamethoxazole, Bactrim, Sulfameth
To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy. Urinary Tract Infections: For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris. It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination. Acute Otitis Media: For the treatment of acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when in the judgment of the physician sulfamethoxazole and trimethoprim offers some advantage over the use of other antimicrobial agents. To date, there are limited data on the safety of repeated use of sulfamethoxazole and trimethoprim in pediatric patients under two years of age. Sulfamethoxazole and trimethoprim is not indicated for prophylactic or prolonged administration in otitis media at any age. Acute Exacerbations of Chronic Bronchitis in Adults: For the treatment of acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzaewhen a physician deems that sulfamethoxazole and trimethoprim could offer some advantage over the use of a single antimicrobial agent. Shigellosis: For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei when antibacterial therapy is indicated. Pneumocystis jiroveci Pneumonia: For the treatment of documented Pneumocystis jiroveci pneumonia and for prophylaxis against P. jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing P. jiroveci pneumonia. Traveler's Diarrhea in Adults: For the treatment of traveler's diarrhea due to susceptible strains of enterotoxigenic E. coli.

Clarithromycin

Generic Name
Clarithromycin

Clarithromycin

Generic Name
Clarithromycin
Clarithromycin is a macrolide antimicrobial indicated for mild to moderate infections caused by designated, susceptible bacteria in the following: Acute Bacterial Exacerbation of Chronic Bronchitis in Adults.

Ofloxacin

Brand Names
Ocuflox, Ofloxacin Ophth, Olfoxacin

Ofloxacin

Brand Names
Ocuflox, Ofloxacin Ophth, Olfoxacin
Ofloxacin Ophthalmic Solution is indicated for the treatment of infections caused by susceptible strains of the following bacteria in the conditions listed below: CONJUNCTIVITIS: Gram-positive bacteria: Staphylococcus aureus Staphylococcus epidermidis Streptococcus pneumoniae Gram-negative bacteria: Enterobacter cloacae Haemophilus influenzae Proteus mirabilis Pseudomonas aeruginosa CORNEAL ULCERS: Gram-positive bacteria: Staphylococcus aureus Staphylococcus epidermidis Streptococcus pneumoniae Gram-negative bacteria: Pseudomonas aeruginosa Serratia marcescens* Anaerobic species: Propionibacterium acnes *Efficacy for this organism was studied in fewer than 10 infections.

Moxifloxacin

Brand Names
Strenza, Vigamox

Moxifloxacin

Brand Names
Strenza, Vigamox
Moxifloxacin is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and older caused by designated susceptible bacteria, in the conditions listed below: Community Acquired Pneumonia.
Showing 1-5 of 14
Not sure about your diagnosis?
Check Your Symptoms
Tired of the same old research?
Check Latest Advances