Restricted Versus Liberal Fluid Intake for Prevention of Bronchopulmonary Dysplasia - RELIEF Trial. A Cluster-randomised Multiple Period Cross-over Trial.
Status: Recruiting
Location: See all (9) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The aim of this study is to determine whether restricted fluid intake (135 ±5 mL/kg/day) compared to liberal fluid intake (165 ±5 mL/kg/day) from day 8 of life reduces the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age or prior death in preterm infants born \<30 weeks gestational age.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 8 days
Healthy Volunteers: f
View:
• Hospitalised preterm infants born before 30 weeks 0 days gestation
• Signed informed consent for further research use of health-related data
Locations
Other Locations
Switzerland
Kantonsspital Aarau AG, Klinik für Kinder u. Jugendliche
RECRUITING
Aarau
University Children's Hospital Basel (UKBB)
RECRUITING
Basel
Inselspital Bern, Kinderklinik
RECRUITING
Bern
Kantonsspital Graubünden, Departement Kinder- und Jugendmedizin
RECRUITING
Chur
Hôpitaux universitaires de Genève (HUG), Unité de Néonatologie
RECRUITING
Geneva
Centre hospitalier universitaire vaudois (CHUV) - Service de néonatologie
RECRUITING
Lausanne
Luzerner Kantonsspital, Kinderspital
RECRUITING
Lucerne
Ostschweizer Kinderspital & Neonatologie und Frauenklinik KSSG, Perinatalzentrum St. Gallen
RECRUITING
Sankt Gallen
UniversitätsSpital Zürich, Klinik für Neonatologie
RECRUITING
Zurich
Contact Information
Primary
Anne Carrer
anne.carrer@ukbb.ch
+4161 704 2853
Backup
Michel Schrutt
relief@ukbb.ch
Time Frame
Start Date: 2025-07-12
Estimated Completion Date: 2029-12
Participants
Target number of participants: 750
Treatments
Experimental: Fluid restriction
Fluid restriction strategy (fluid target 135 ±5 mL/kg/d). This is standard of care.
Active_comparator: Liberal fluid intake
Liberal fluid intake strategy (fluid target 165 ± 5 mL/kg/d) in line with international best practice recommendations on nutrition.
Related Therapeutic Areas
Sponsors
Collaborators: Swiss Neonatal Network
Leads: University Children's Hospital Basel