Developing a National Approach to Surveillance and Prevention for Neonatal Ventilator-Associated Pneumonia

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born very early (preterm) or very small who often require respiratory support in hospital's neonatal intensive care units (NICUs). The main questions it aims to answer are: * How often do very-low-birth-weight (VLBW) infants get ventilator-associated pneumonia (VAP) in hospitals across Canada? * How often are these VAP infections caused by germs that are resistant to antimicrobials (also known as antimicrobial-resistant organisms or AROs)? * What types of antimicrobial-resistant germs (AROs) are causing them? * How are these infections being treated with antibiotics, and can we reduce unnecessary antibiotic use? * Which diagnostic definition is the best and most accurate for diagnosing VAP in newborns, based on real patient data and expert agreement? * Can we use this information to create clear, evidence-based guidelines that help hospitals prevent and treat VAP in the same, effective way? Researchers will compare how different hospitals define, report, and manage VAP to devise a shared, evidence-based approach that will lead to more accurate diagnoses and better treatment and outcomes for neonatal VAP. Researchers will: * Use data already collected in hospital records (per existing standard of clinical care). * Analyse how often VAP occurs, how it is diagnosed, and how it is treated * Work with experts and hospitals to develop and implement a standard, evidence-based plan for diagnosing, managing and preventing VAP in newborns The overarching goal is to create a clear, nationwide approach to ensure hospitals across Canada care for preterm babies in a standardized manner, reduce infection rates, avoid unnecessary antibiotic use, and improve outcomes for these vulnerable infants.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 5 months
Healthy Volunteers: f
View:

• All VLBW infants admitted to participating tertiary NICUs in Canada

• All neonatal VAP events diagnosed based on the physicians' discretion

Locations
Other Locations
Canada
Royal Alexandra Hospital
RECRUITING
Edmonton
Contact Information
Primary
Dr. Joseph Ting, Staff Neonatologist and Clinical Research Professor
joseph.ting@ualberta.ca
+1(780) 248-5408
Backup
Christie (Zixuan) Li, Clinical Research Coordinator, BSc, MSc
christie.zx.li@ualberta.ca
Time Frame
Start Date: 2025-12-31
Estimated Completion Date: 2029-09
Participants
Target number of participants: 1500
Treatments
VLBW infants with VAP Diagnosis
The study population will include all VLBW infants (birth weight \<1500g) admitted to participating tertiary NICUs in Canada with diagnoses of VAP at physicians' discretion.
Related Therapeutic Areas
Sponsors
Collaborators: McGill University, University of British Columbia, University of Toronto, University of Calgary
Leads: University of Alberta

This content was sourced from clinicaltrials.gov