Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Brucellosis?

Brucellosis is a bacterial infection that occurs from contact with animals carrying brucella bacteria.

What are the alternative names for Brucellosis?

Cyprus fever; Undulant fever; Gibraltar fever; Malta fever; Mediterranean fever

What are the causes for Brucellosis?

Brucella can infect cattle, goats, camels, dogs, and pigs. The bacteria can spread to humans if you come in contact with infected meat or the placenta of infected animals, or if you eat or drink unpasteurized milk or cheese.

Brucellosis is rare in the United States. About 100 to 200 cases occur each year. Most cases are caused by the Brucellosis melitensis bacteria.

People working in jobs where they often come in contact with animals or meat -- such as slaughterhouse workers, farmers, and veterinarians -- are at higher risk.

What are the symptoms for Brucellosis?

Acute brucellosis may begin with mild flu-like symptoms, or symptoms such as:

  • Abdominal pain
  • Back pain
  • Fever and chills
  • Excessive sweating
  • Fatigue
  • Headache
  • Joint and muscle pain
  • Loss of appetite
  • Swollen glands
  • Weakness
  • Weight loss

High fever spikes often occur every afternoon. The name undulant fever is often used to describe this disease because the fever rises and falls in waves.

The illness may be chronic and last for years.

What are the current treatments for Brucellosis?

Antibiotics, such as doxycycline, streptomycin, gentamicin, and rifampin, are used to treat the infection and prevent it from coming back. Often, you need to take the drugs for 6 weeks. If there are complications from brucellosis, you will likely need to take the drugs for a longer period.

What is the outlook (prognosis) for Brucellosis?

Symptoms may come and go for years. Also, the illness can come back after a long period of not having symptoms.

What are the possible complications for Brucellosis?

Health problems that may result from brucellosis include:

  • Bone and joint sores (lesions)
  • Encephalitis (swelling, or inflammation, of the brain)
  • Infective endocarditis (inflammation of the inside lining of the heart chambers and heart valves)
  • Meningitis (infection of the membranes covering the brain and spinal cord)

When should I contact a medical professional for Brucellosis?

Call for an appointment with your provider if:

  • You develop symptoms of brucellosis
  • Your symptoms get worse or do not improve with treatment
  • You develop new symptoms

How do I prevent Brucellosis?

Drinking and eating only pasteurized dairy products, such as milk and cheeses, is the most important way to reduce the risk for brucellosis. People who handle meat should wear protective eyewear and clothing, and protect skin breaks from infection.

Detecting infected animals controls the infection at its source. Vaccination is available for cattle, but not humans.



Gotuzzo E, Ryan ET. Brucellosis. In: Ryan ET, Hill DR, Solomon T, Aronson NE, Endy TP, eds. Hunter's Tropical Medicine and Emerging Infectious Diseases. 10th ed. Philadelphia, PA: Elsevier; 2020:chap 75.

Gul HC, Erdem H. Brucellosis (Brucella species). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 226.

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Latest Research

Latest Advance
  • Condition: Brucellosis-induced reproductive system damage
  • Journal: The Journal of international medical research
  • Treatment Used: Rifampicin+doxycycline
  • Number of Patients: 22
  • Published —
The study researched brucellosis-induced reproductive system damage.
Latest Advance
  • Condition: Pulmonary Valve Endocarditis Due to Brucellosis
  • Journal: BMJ case reports
  • Treatment Used: Triple Therapy
  • Number of Patients: 1
  • Published —
This study evaluated the effectiveness of triple therapy in a patient with pulmonary valve endocarditis (rare type of infection in the inner lining of the heart chambers and heart valves) due to brucellosis (bacterial infection).

Clinical Trials

Clinical Trial
  • Status: Recruiting
  • Study Type: Drug
  • Participants: 10000
  • Start Date: May 13, 2020
Real World Study of Classic Infectious Disease
Clinical Trial
  • Status: Active, not recruiting
  • Study Type: Other
  • Participants: 1800
  • Start Date: September 4, 2019
Livestock Programming for Nutritional Improvements in Pregnant, Lactating Mothers and Children Under Five Years of Age in Marsabit County, Kenya