Learn About Brugada Syndrome
Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm. Specifically, this disorder can lead to irregular heartbeats in the heart's lower chambers (ventricles), which is an abnormality called ventricular arrhythmia. If untreated, the irregular heartbeats can cause fainting (syncope), seizures, difficulty breathing, or sudden death. These complications typically occur when an affected person is resting or asleep.
Brugada syndrome can be caused by mutations in one of several genes. The most commonly mutated gene in this condition is SCN5A, which is altered in approximately 30 percent of affected individuals. This gene provides instructions for making a sodium channel, which normally transports positively charged sodium atoms (ions) into heart muscle cells. This type of ion channel plays a critical role in maintaining the heart's normal rhythm. Mutations in the SCN5A gene alter the structure or function of the channel, which reduces the flow of sodium ions into cells. A disruption in ion transport alters the way the heart beats, leading to the abnormal heart rhythm characteristic of Brugada syndrome.
The exact prevalence of Brugada syndrome is unknown, although it is estimated to affect 5 in 10,000 people worldwide. This condition occurs much more frequently in people of Asian ancestry, particularly in Japanese and Southeast Asian populations.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition. Other cases may result from new mutations in the gene. These cases occur in people with no history of the disorder in their family.
Vanderbilt University Medical Center
Dan Roden is a Cardiologist in Nashville, Tennessee. Dr. Roden and is rated as an Elite provider by MediFind in the treatment of Brugada Syndrome. His top areas of expertise are Long QT Syndrome 5, Long QT Syndrome, Brugada Syndrome, Cardiac Ablation, and Percutaneous Coronary Intervention (PCI). Dr. Roden is currently accepting new patients.
Vanderbilt University Medical Center
Christopher Ellis is a Cardiologist and a Cardiac Electrophysiologist in Nashville, Tennessee. Dr. Ellis and is rated as a Distinguished provider by MediFind in the treatment of Brugada Syndrome. His top areas of expertise are Atrial Fibrillation, Arrhythmias, Sick Sinus Syndrome, Cardiac Ablation, and Pacemaker Implantation. Dr. Ellis is currently accepting new patients.
Centennial Heart LLC
John Riddick is an Interventional Cardiologist and a Cardiologist in Nashville, Tennessee. Dr. Riddick and is rated as an Advanced provider by MediFind in the treatment of Brugada Syndrome. His top areas of expertise are Aortic Regurgitation, Necrosis, Aortic Valve Stenosis, Aortic Valve Replacement, and Transcatheter Aortic Valve Replacement (TAVR). Dr. Riddick is currently accepting new patients.
Summary: The purpose is to increase the understanding of the characteristics, circumstances, medical histories and pathologies of children from ages 11 months through 18 years who have died suddenly and unexpectedly, and in some instances, without explanation. The SUDC Registry and Research Collaborative will analyze cases of sudden unexpected deaths in these children to understand risk factors and causes,...
Summary: Independent, single center, prospective study, to evaluate the efficacy, in consecutive BrS patients undergoing catheter ablation, at medium-long term follow-up after epicardial substrate homogenization. The target area is defined collecting signals using high density and high resolution mapping with equi-spaced electrode array. The ablation of abnormal fragmented prolonged low-frequency ventricul...
Published Date: March 01, 2015
Published By: National Institutes of Health