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Condition

Budd-Chiari Syndrome

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Budd-Chiari Syndrome?

Budd-Chiari syndrome is a rare disorder characterized by obstruction of the veins of the liver that carry the blood flow from the liver. When the blood flow out of the liver is impeded, blood backs up in the liver, causing it to enlarge (hepatomegaly). The spleen may also enlarge ...

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What are the alternative names for Budd-Chiari Syndrome?

  • Membranous obstruction of the inferior vena cava

What are the current treatments for Budd-Chiari Syndrome?

The treatment of Budd-Chiari syndrome varies, depending on the cause of the blockage. Medical treatments may include:
  • Blood-thinning (anticoagulation) medications
  • Clot-busting drugs (thrombolytic treatment)
  • Treatment for the liver disease, including ascites

Surgical treatments may also be considered and include:

  • Angioplasty and stent placement
  • Transjugular intrahepatic portosystemic shunt (TIPS)
  • Venous shunt surgery

While medical therapy can be instituted for short-term, symptomatic benefit, medical therapy alone has been associated with a high 2-year mortality rate (80-85%).

In cases of severe cirrhosis liver transplant may be needed. You can view more detailed information regarding the medical and surgical options for treatment of Budd-Chiari syndrome by visiting the Medscape Reference website on Budd-Chiari syndrome treatment & managment. You may need to register to view the article, but registration is free.

Top Global Doctors

Latest Research

Latest Advance
Study
  • Condition: Pediatric Hepatic Venous Outflow Tract Obstruction
  • Journal: Indian pediatrics
  • Treatment Used: Angioplasty or Liver Transplantation
  • Number of Patients: 11
  • Published —
This study reviewed case records of children diagnosed with hepatic venous outflow tract obstruction.
Latest Advance
Study
  • Condition: Budd-Chiari Syndrome Associated With Hypereosinophilic Syndrome
  • Journal: Transplantation proceedings
  • Treatment Used: Deceased-Donor Liver Transplantation
  • Number of Patients: 1
  • Published —
The study measured performing a liver transplant from a deceased person to treat Budd-Chiari syndrome associated with hypereosinophilic syndrome.
Latest Advance
Study
  • Condition: Budd-Chiari Syndrome
  • Journal: The lancet. Gastroenterology & hepatology
  • Treatment Used: Angioplasty with vs. without Routine Stent Placement
  • Number of Patients: 88
  • Published —
This study tested whether use of routine, non-selective stenting in angioplasty could improve patency and treatment efficacy with adequate safety in Budd-Chiari syndrome (occlusion of hepatic veins).
Latest Advance
Study
  • Condition: Budd-Chiari Syndrome (BCS) Accompanied with Inferior Vena Cava Thrombosis
  • Journal: Annals of vascular surgery
  • Treatment Used: Pre-Opening and Staged Percutaneous Transluminal Angioplasty (PTA) of the Inferior Vena Cava
  • Number of Patients: 88
  • Published —
This study analyzed the clinical effectiveness and safety of traditional open operations versus pre-opening and staged percutaneous transluminal angioplasty (PTA) of the inferior vena cava in treating Budd-Chiari syndrome (occlusion of hepatic vein; BCS) accompanied with inferior vena cava thrombosis.

Clinical Trials

Clinical Trial
Radiation
  • Status: Active, not recruiting
  • Study Type: Radiation
  • Participants: 86
  • Start Date: April 20, 2018
Phase II Study of Concurrent Sorafenib and Intensity-modulated Radiotherapy (IMRT) for Advanced Hepatocellular Carcinoma
Clinical Trial
Other
  • Status: Recruiting
  • Participants: 150
  • Start Date: December 12, 2017
Vienna Vascular Liver Disease Study: Characterization of Patients With Vascular Liver Disease - a Registry With Biobank
Clinical Trial
Other
  • Status: Recruiting
  • Study Type: Other
  • Participants: 110
  • Start Date: December 7, 2016
The Perioperative Liberal or Restrictive Transfusion in Pediatric Liver Transplantation: A Prospective Randomized Controlled Trial