Buerger Disease
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Buerger Disease Overview

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Learn About Buerger Disease

What is the definition of Buerger Disease?
Buerger disease is a disease in which small and medium-sized blood vessels in the arms and/or legs become inflamed and blocked (vasculitis). This reduces blood flow to affected areas of the body, eventually resulting damage to tissues. Symptoms of Buerger disease may include coldness, numbness, tingling or burning, and pain. Symptoms may first be felt in the fingertips or toes, and then move further up the arms or legs. Additional symptoms that may develop include changes in the texture and color of the skin, Raynaud's phenomenon, painful muscle cramps, swelling (edema), skin ulcers, and gangrene. Buerger disease almost always occurs in people who use tobacco, but it is not known exactly how tobacco plays a role in the development of the disease. Some people may have a genetic predisposition to Buerger disease. It is also possible that Buerger disease is an autoimmune disease, as the immune system seems to play a large role in its development.
What are the alternative names for Buerger Disease?
  • Buerger disease
  • Buerger's disease
  • Inflammatory occlusive peripheral vascular disease
  • Occlusive peripheral vascular disease
  • TAO
  • Thromboangiitis obliterans
Who are the top Buerger Disease Local Doctors?
Elite in Buerger Disease
Patrice P. Cacoub
Elite in Buerger Disease
Patrice P. Cacoub
Paris, FR 

Patrice Cacoub practices practicing medicine in Paris, France. Mr. Cacoub is rated as an Elite expert by MediFind in the treatment of Buerger Disease. He is also highly rated in 42 other conditions, according to our data. His clinical expertise encompasses Cryoglobulinemia, Vasculitis, Takayasu Arteritis, Vitrectomy, and Leg or Foot Amputation.

Elite in Buerger Disease
Yukihito Higashi
Elite in Buerger Disease
Yukihito Higashi
Hiroshima, JP 

Yukihito Higashi practices practicing medicine in Hiroshima, Japan. Higashi is rated as an Elite expert by MediFind in the treatment of Buerger Disease. They are also highly rated in 12 other conditions, according to our data. Their clinical expertise encompasses Buerger Disease, Thromboangiitis Obliterans, Atherosclerosis, Hypertension, and Bone Marrow Transplant.

 
 
 
 
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Elite in Buerger Disease
Alexandre Le Joncour
Elite in Buerger Disease
Alexandre Le Joncour
Paris, FR 

Alexandre Le Joncour practices practicing medicine in Paris, France. Mr. Le Joncour is rated as an Elite expert by MediFind in the treatment of Buerger Disease. He is also highly rated in 5 other conditions, according to our data. His clinical expertise encompasses Buerger Disease, Thromboangiitis Obliterans, Vasculitis, and Behcet Disease.

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What are the latest Buerger Disease Clinical Trials?
A First in Human, Double-Blind, Placebo-Controlled, Randomized Evaluation of Single Ascending Doses of ATI-1013, a Human Monoclonal Antibody to Nicotine in Healthy Smokers
A First in Human, Double-Blind, Placebo-Controlled, Randomized Evaluation of Single Ascending Doses of ATI-1013, a Human Monoclonal Antibody to Nicotine in Healthy Smokers
Enrollment Status: Recruiting
Publish Date: October 15, 2025
Intervention Type: Other, Biological
Study Phase: Phase 1

Summary: This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the body, does drug ATI-1013 trigger an immune response, and the effects of drug ATI-1013 on nicotine levels within the body. The clinical trial will compare drug ATI-1013 to a ...

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An Observational, Practice-Based, Open Label, Feasibility Study to Observe the Efficacy and Safety of Intramuscular Administration of Stempeucel® in Malaysian Patients With Critical Limb Ischemia (CLI) Due to Buerger's Disease
An Observational, Practice-Based, Open Label, Feasibility Study to Observe the Efficacy and Safety of Intramuscular Administration of Stempeucel® in Malaysian Patients With Critical Limb Ischemia (CLI) Due to Buerger's Disease
Enrollment Status: Recruiting
Publish Date: September 09, 2025
Intervention Type: Biological
Study Phase: Phase 4

Summary: The goal of this observational, practice-based feasibility study is to observe the efficacy and safety of intramuscular administration of Stempeucel® in Malaysian patients with critical limb ischemia (CLI) due to Buerger's disease. The main questions it aims to answer are: * Can intramuscular administration of Stempeucel® reduce symptoms of CLI due to Buerger's disease while improving the healing ...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center