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Condition

Buerger Disease

Condition 101

What is the definition of Buerger Disease?

Buerger disease is a disease in which small and medium-sized blood vessels in the arms and/or legs become inflamed and blocked (vasculitis). This reduces blood flow to affected areas of the body, eventually resulting damage to tissues. Symptoms of Buerger disease may include cold ...

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What are the alternative names for Buerger Disease?

  • Buerger's disease
  • Thromboangiitis obliterans
  • TAO
  • Inflammatory occlusive peripheral vascular disease
  • Occlusive peripheral vascular disease

What are the causes for Buerger Disease?

Buerger disease has a strong relationship to cigarette smoking. This association may be due to direct poisoning of cells from some component of tobacco, or by hypersensitivity to the same components. Many people with Buerger disease will show hypersensitivities to injection of tobacco extracts into their skin. There may be a genetic component to susceptibility to Buerger disease as well. It is possible that these genetic influences account for the higher prevalence of Buerger disease in people of Israeli, Indian subcontinent, and Japanese descent. Certain HLA (human leukocyte antigen) haplotypes have also been found in association with Buerger disease.

What are the current treatments for Buerger Disease?

Currently there is not a cure for Buerger disease, however there are treatments that can help control it. The most essential part of treatment is to avoid all tobacco and nicotine products. Even one cigarette a day can worsen the disease. A doctor can help a person with Buerger disease learn about safe medications and programs to combat smoking/nicotine addiction. Continued smoking is associated with an overall amputation rate of 40 to 50 percent.

The following treatments may also be helpful, but do not replace smoking/nicotine cessation:

Medications to dilate blood vessels and improve blood flow (e.g., intravenous Iloprost)
Medications to dissolve blood clots
Treatment with calcium channel blockers
Walking exercises
Intermittent compression of the arms and legs to increase blood flow to your extremities
Surgical sympathectomy (a controversial surgery to cut the nerves to the affected area to control pain and increase blood flow)
Therapeutic angiogenesis (medications to stimulate growth of new blood vessels)
Spinal cord stimulation
Amputation, if infection or gangrene occurs

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Latest Research

Latest Advance
Study
  • Condition: Diabetic Foot
  • Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • Treatment Used: Tibial Transverse Transport (TTT)
  • Number of Patients: 516
  • Published —
This study reported results on tibial transverse transport (TTT) for the treatment of diabetic foot.
Latest Advance
Study
  • Condition: Chronic Infection of Foot and Ankle with Lower Extremity Ischemic Diseases
  • Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • Treatment Used: Tibial Transverse Transport Combined with Antibiotic Embedded Bone Cement
  • Number of Patients: 28
  • Published —
This study evaluated the effectiveness of tibial transverse transport combined with the antibiotics embedded bone cement in the treatment of chronic infection of foot and ankle with lower extremity ischemic diseases.
Latest Advance
Study
  • Condition: Buerger's Disease
  • Journal: The Cochrane database of systematic reviews
  • Treatment Used: Pharmacological Treatment
  • Number of Patients: 602
  • Published —
This study assessed the effectiveness of any pharmacological agent (intravenous or oral) compared with placebo or any other pharmacological agent in patients with Buerger's disease (inflammatory disease; thromboangiitis obliterans).
Latest Advance
Study
  • Condition: Thromboangiitis Obliterans (Buerger Disease)
  • Journal: Advances in skin & wound care
  • Treatment Used: Smoking Cessation, Fat Grafting, and Other Treatments
  • Number of Patients: 1
  • Published —
This case report discusses a 29-year-old smoker diagnosed with Thromboangiitis obliterans, or Buerger disease, a rare non-atherosclerotic segmental inflammatory vasculitis that generally affects young tobacco smokers, and who was treated with fifth left toe amputation, hyperbaric therapy, and lipofilling using the Coleman technique.