Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:
• Female
• Aged 18 to 45 years
• Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2
• Right-handed
• English-speaking
⁃ Additional Inclusion Criteria for Women with Bulimia Nervosa:
• Meet DSM-5 criteria for bulimia nervosa
Locations
United States
New York
Center of Excellence in Eating and Weight Disorders at the Icahn School of Medicine at Mount Sinai
RECRUITING
New York
Contact Information
Primary
Jiulin Dai, B.S.
jiulin.dai@mssm.edu
212-824-9561
Backup
Riley Macks
riley.macks@mssm.edu
(212) 824-9545
Time Frame
Start Date: 2023-12-12
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 150
Treatments
Experimental: Participants with Bulimia Nervosa
Participants are randomly assigned (in even numbers across the two groups) to scan order:~A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day.~B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.
Active_comparator: Participants without Bulimia Nervosa
Participants are randomly assigned (in even numbers across the two groups) to scan order:~A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day.~B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Mental Health (NIMH)
Leads: Icahn School of Medicine at Mount Sinai