What is the definition of Bullous Pemphigoid?

Bullous pemphigoid is a skin disorder characterized by blisters.

What are the causes for Bullous Pemphigoid?

Bullous pemphigoid is an autoimmune disorder that occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Specifically, the immune system attacks the proteins that attach the top layer of skin (epidermis) to the bottom layer of skin.

This disorder usually occurs in older persons and is rare in young people. Symptoms come and go. The condition often goes away within 5 years.

What are the symptoms for Bullous Pemphigoid?

Most people with this disorder have itchy skin that may be severe. In most cases, there are blisters, called bullae.

  • Blisters are usually located on the arms, legs, or middle of the body. In rare cases, blisters can form in the mouth.
  • The blisters may break open and form open sores (ulcers).

What are the current treatments for Bullous Pemphigoid?

Anti-inflammatory medicines called corticosteroids may be prescribed. They may be taken by mouth or applied to the skin. More powerful medicines may be used to help suppress the immune system if steroids do not work, or to allow lower steroid doses to be used.

Antibiotics in the tetracycline family may be useful. Niacin (a B complex vitamin) is sometimes given along with tetracycline.

Your provider may suggest self-care measures. These may include:

  • Applying anti-itch creams to the skin
  • Using mild soaps and applying moisturizer to the skin after bathing
  • Protecting the affected skin from sun exposure and from injury

What is the outlook (prognosis) for Bullous Pemphigoid?

Bullous pemphigoid usually responds well to treatment. The medicine can often be stopped after several years. The disease sometimes returns after treatment is stopped.

What are the possible complications for Bullous Pemphigoid?

Skin infection is the most common complication.

Complications resulting from treatment may also occur, especially from taking corticosteroids.

When should I contact a medical professional for Bullous Pemphigoid?

Contact your provider if you have:

  • Unexplained blisters on your skin
    Unexplained blisters on your skin
  • An itchy rash that continues despite home treatment
    An itchy rash that continues despite home treatment


Habif TP. Vesicular and bullous diseases. In: Habif TP, ed. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 6th ed. Philadelphia, PA: Elsevier; 2016:chap 16.

PeñaS, Werth VP. Bullous pemphigoid. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 33.

  • Condition: Acquired Hemophilia A (AHA)
  • Journal: Medicine
  • Treatment Used: Rituximab and rFVIIa
  • Number of Patients: 1
  • Published —
This article reviewed the case of a patient with acquired hemophilia A (bleeding disorder that interferes with the body's blood clotting process; AHA) treated with rituximab and rFVIIA.
  • Condition: Bullous Pemphigoid (BP) Induced by Ustekinumab
  • Journal: European journal of hospital pharmacy : science and practice
  • Treatment Used: Corticosteroids, Dapsone, and Ustekinumab Discontinuation
  • Number of Patients: 1
  • Published —
This case report describes a 75-year-old woman diagnosed with bullous pemphigoid (skin lesions; BP) induced by ustekinumab treated with corticosteroids, dapsone, and ustekinumab discontinuation.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 3
  • Intervention Type: Drug
  • Participants: 15
  • Start Date: May 25, 2021
An Open-Label Study to Evaluate the Efficacy and Safety of Rituximab Combined With Omalizumab in Patients With Bullous Pemphigoid
Clinical Trial
  • Status: Not yet recruiting
  • Participants: 45
  • Start Date: May 2021
Improving Clinical Trial Recruitment and Outcome Measures in Bullous Pemphigoid