C3 GlomerulopathySymptoms, Doctors, Treatments, Advances & More
Learn About C3 Glomerulopathy
C3 glomerulopathy is a group of related conditions that cause the kidneys to malfunction. The major features of C3 glomerulopathy include high levels of protein in the urine (proteinuria), blood in the urine (hematuria), reduced amounts of urine, low levels of protein in the blood, and swelling in many areas of the body. Affected individuals may have particularly low levels of a protein called complement component 3 (or C3) in the blood.
C3 glomerulopathy is associated with changes in many genes. Most of these genes provide instructions for making proteins that help regulate a part of the body's immune response known as the complement system. This system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. The complement system must be carefully regulated so it targets only unwanted materials and does not damage the body's healthy cells.
C3 glomerulopathy is very rare, affecting 1 to 2 per million people worldwide. It is equally common in men and women.
Most cases of C3 glomerulopathy are sporadic, which means they occur in people with no history of the disorder in their family. Only a few reported families have had more than one family member with C3 glomerulopathy. However, many affected people have had close relatives with autoimmune diseases, which occur when the immune system malfunctions and attacks the body's tissues and organs. The connection between C3 glomerulopathy and autoimmune diseases is not fully understood.
Nephrology Associates Of Northern Illinois, Ltd
Sumit Bector is a Nephrologist in Elgin, Illinois. Dr. Bector is rated as an Advanced provider by MediFind in the treatment of C3 Glomerulopathy. His top areas of expertise are Acute Kidney Failure, Necrosis, Nephrosclerosis, and Renovascular Hypertension.
Opeyemi Oladele is a Nephrologist in Barstow, California. Dr. Oladele is rated as an Advanced provider by MediFind in the treatment of C3 Glomerulopathy. His top areas of expertise are Acute Kidney Failure, Necrosis, Chronic Kidney Disease, and End-Stage Renal Disease (ESRD). Dr. Oladele is currently accepting new patients.
Johns Hopkins Outpatient Center
Dr. C. John Sperati is an Associate Professor of Medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include renal medicine. Dr. Sperati is Director of the Glomerular Diseases Fellowship Program since 2023 and formerly directed the Nephrology Fellowship Training Program from 2019 - 2025. He was the long-serving Firm Faculty Leader of the Barker Firm and has held leadership positions within the Osler Medical Residency training program. In addition, he co-directs the Johns Hopkins Osler Learning Initiative which brings the principles of medical residency training to executive education worldwide. He obtained his medical degree from The Pennsylvania State University College of Medicine and a Master in Health Science from the Johns Hopkins Bloomberg School of Public Health. He completed an internship and residency in Internal Medicine at the Johns Hopkins Hospital, followed by a year as an Assistant Chief of Service (chief resident). He subsequently pursued subspecialty training in nephrology at the Johns Hopkins Hospital and joined the faculty in the Division of Nephrology. Dr. Sperati’s clinical interests are in thrombotic microangiopathy including atypical hemolytic uremic syndrome (aHUS), complement-mediated kidney diseases including C3 glomerulopathy, glomerular disease such as glomerulonephritis (e.g., IgA nephropathy, MPGN) and nephrotic syndromes (e.g., FSGS, membranous, minimal change, amyloidosis, and others), and secondary and resistant hypertension (e.g., fibromuscular dysplasia, atherosclerotic renal arterial disease, hyperaldosteronism, and genetic hypertensive syndromes). He is the site principal investigator for clinical trials in glomerular disease, serves on editorial boards, and chairs the approval committee of the Longitudinal Knowledge Assessment for nephrology for the American Board of Internal Medicine. His clinical acumen and educational contributions have been recognized by induction into the Miller Coulson Academy of Clinical Excellence as well as the American Society of Nephrology Distinguished Educator Award in 2020. He has been recognized as a physician resource through the Atypical HUS Foundation, a NephCure glomerular disease specialist, an IgA Nephropathy Foundation specialist, and a Baltimore TopDoc. He is registered with the Florida Department of Health to perform telehealth services for patients in Florida. Dr. Sperati is rated as an Experienced provider by MediFind in the treatment of C3 Glomerulopathy. His top areas of expertise are Atypical Hemolytic Uremic Syndrome (aHUS), Hemolytic-Uremic Syndrome, D-Plus Hemolytic Uremic Syndrome, Glomerulonephritis, and Kidney Transplant.
Published Date: December 01, 2015
Published By: National Institutes of Health