Natural History of Cardiac Transthyretin Amyloidosis - Mechanistic Insights by Multimodality Imaging

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to investigate whether new imaging techniques can help us to better understand the cardiac amyloidosis. The disease can be slowed down with various medications (e.g., tafamidis, acoramidis, or vutrisiran). However, treatment is not effective in all patients-in about one-third of cases, the disease continues to progress. So far, we know little about the exact causes of this and what biological changes occur in the heart muscle. The main question it aims to answer is: Will new imaging techniques help us understand the course of the cardiac amyloidosis? Participants will have additional examinations: * At the beginning of the study: one additional heart ultrasound examination, one cardiac MRI and one cardiac PET, blood examination during the regular examination, questionnaires. * After a year: one additional heart ultrasound examination, one cardiac MRI and one cardiac PET, blood examination during the regular examination. Time required: * Heart ultrasound examination: 5-10 Minutes * Cardiac MRI: 2 hours * Cardiac PET: 2 hours * Questionnaires: 5-10 Minutes.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Participants with cardiac ATTR amyloidosis, as recently defined by multi-societal criteria, who are about to start tafamidis at the University Hospital Zurich

Locations
Other Locations
Switzerland
University Hospital Zurich
RECRUITING
Zurich
Contact Information
Primary
Dominik C Benz, PD Dr. med.
dominik.benz@usz.ch
+41432531191
Time Frame
Start Date: 2025-10-20
Estimated Completion Date: 2027-06
Participants
Target number of participants: 50
Treatments
Experimental: 18F-FAPI PET/CT
Additional imaging including 18F-FAPI PET/CT is performed
Sponsors
Collaborators: Olga Mayenfisch Stiftung, Zurich, Switzerland, University of Zurich
Leads: Dominik Benz

This content was sourced from clinicaltrials.gov