Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study. The Crush or Crash Study.

Status: Recruiting
Location: See all (42) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

There is a great heterogeneity in the practice of rapid sequence induction in the operating room in the world. There are no recent data assessing the rate of implementation of the latest French formalized expert recommendations in clinical practice. In addition, the modalities for the management of haemodynamic disorders, particularly hypotensive disorders, during rapid sequence induction are not described in these recommendations, although these are frequent events with a non-zero morbidity mortality potential. The goal of this prospective, observational, multicenter, anesthetic study is to describe the clinical practice of French anesthesiologists regarding the prevention of severe hemodynamic disorders during rapid sequence anesthetic induction in adult patients. The primary outcome measure is the occurrence of a major haemodynamic disorder defined by a MBP ≤ 50 mmHg (or ≤ 40% of the reference value) and/or ≥ 110 mmHg and/or the occurrence of sustained arrhythmia not present at induction and/or cardiac arrest within the first 10 minutes after induction of anesthesia. The clinical practices of pre-oxygenation, induction and intubation of French anesthesiologists and compliance with the formalized expert recommendations of 2017 and 2018 will also be studied secondarily. The elements for the prevention of gastric fluid inhalation, the organization and equipment used, the anesthetic and non-anesthetic drugs used, the clinical and paraclinical neurological and cardio-respiratory parameters and the nature of the complications following anaesthetic induction will be collected up to the 10th post-induction minute.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years' old

• Procedure requiring general anesthesia with oro or nasotracheal intubation

• Anesthetic management with indication of rapid sequence induction

• No objection after oral and written information to the patient

Locations
Other Locations
France
Clinique Victor Pauchet
RECRUITING
Amiens
Hospital
RECRUITING
Arcachon
Hospital
RECRUITING
Armentières
Hôpital Privé Arras les Bonnettes
RECRUITING
Arras
University Hospital
RECRUITING
Brest
University Hospital
RECRUITING
Caen
Centre Hospitalier Intercommunal
RECRUITING
Castres
University Hospital
RECRUITING
Clermont-ferrand
CHD Vendée
RECRUITING
La Roche-sur-yon
University Hospital
NOT_YET_RECRUITING
Lille
Hospital
RECRUITING
Lorient
Centre Léon Bérard
RECRUITING
Lyon
Clinique de la Sauvegarde
RECRUITING
Lyon
Saint Joseph Saint Luc Hospital
RECRUITING
Lyon
University Hopital - Edouard Herriot
RECRUITING
Lyon
University Hospital - Sud
RECRUITING
Lyon
Hospital
NOT_YET_RECRUITING
Mont-de-marsan
Hospital
RECRUITING
Montargis
University Hospital
RECRUITING
Nantes
University Hospital - Pasteur
RECRUITING
Nice
Bichat Hospital - APHP
RECRUITING
Paris
Hopital Lariboisiere - APHP
RECRUITING
Paris
Hopital Pitié Salpetriere - APHP
RECRUITING
Paris
Hopital Saint Louis, Lariboisiere, Fernand Widal - APHP
RECRUITING
Paris
Hôpital Tenon - APHP
RECRUITING
Paris
University Hospital
NOT_YET_RECRUITING
Poitiers
Clinique de la Sagesse
RECRUITING
Rennes
Hospital
RECRUITING
Rodez
Yves Le Foll Hospital
NOT_YET_RECRUITING
Saint-brieuc
University Hospital La Réunion - Site Nord
RECRUITING
Saint-denis
University Hospital La Réunion - site Ouest
RECRUITING
Saint-paul
Groupe Hospitalier Seclin Carvin
NOT_YET_RECRUITING
Seclin
Centre Clinical - Angoulême
RECRUITING
Soyaux
Hospital
RECRUITING
St-malo
Clinique Rhéna
RECRUITING
Strasbourg
University Hospital - Hautepierre
RECRUITING
Strasbourg
Hôpitaux du Leman
RECRUITING
Thonon-les-bains
Centre hospitalier intercommunal
RECRUITING
Toulon
University Hospital - Rangueil
NOT_YET_RECRUITING
Toulouse
Hospital
RECRUITING
Valenciennes
Institut Gustave Roussy
NOT_YET_RECRUITING
Villejuif
Clinique de Villeneuve Saint Georges
NOT_YET_RECRUITING
Villeneuve-saint-georges
Contact Information
Primary
Hugo Ingles, MD
hugo.ingles@chu-nantes.fr
+33.2.40.08.73.80
Backup
Nicolas Grillot, MD
nicolas.grillot@chu-nantes.fr
+33.2.40.08.73.80
Time Frame
Start Date: 2023-11-15
Estimated Completion Date: 2025-05-15
Participants
Target number of participants: 1150
Related Therapeutic Areas
Sponsors
Leads: Nantes University Hospital
Collaborators: Société Française d'Anesthésie et de Réanimation

This content was sourced from clinicaltrials.gov