The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.

Status: Recruiting
Location: See all (5) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR. This study aims to determine if using PEEP during CPR helps restart the heart more effectively, improves survival rates, and enhances survival with good neurologic outcomes after a cardiac arrest compared to standard CPR without PEEP. Researchers will randomly assign participants to one of two groups: one receiving CPR with PEEP set at 5 cm of water pressure and the other receiving standard CPR without PEEP. Participants will be treated by emergency medical teams trained in advanced life support, and specialised sensors will measure airflow and airway pressure during resuscitation. Additionally, the study will evaluate potential side effects associated with PEEP, such as increased pressure within the chest or lung injuries. Findings from this trial will guide recommendations on the usage of PEEP in standard CPR practices to potentially improve patient outcomes.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age: Adults aged 18 years and older.

• Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.

• CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.

• Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.

Locations
Other Locations
Belgium
AZORG: campus Merestraat
RECRUITING
Aalst
AZORG: Campus Moorselbaan
RECRUITING
Aalst
AZORG: campus Geraardsbergen
RECRUITING
Geraardsbergen
UZ Ghent
RECRUITING
Ghent
AZ Zeno
RECRUITING
Knokke
Contact Information
Primary
Thomas Tackaert, MD
thomas.tackaert@ugent.be
0032 53 72 49 96
Time Frame
Start Date: 2025-04-25
Estimated Completion Date: 2027-02-01
Participants
Target number of participants: 132
Treatments
Experimental: Intervention
Ventilation during cardiac arrest with an adult Resuscitation Bag with a pressure relief valve set at 40 cm H20 and a disposable PEEP Valve set at 5 cm H20.
Active_comparator: Controle
Ventilation during cardiac arrest with an adult Resuscitation Bag with a pressure relief valve set at 40 cm H20 without a disposable PEEP Valve.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Ghent

This content was sourced from clinicaltrials.gov

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