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Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 day
Maximum Age: 17
Healthy Volunteers: f
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• Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English

• Mechanically ventilated (Endotracheal tube)

• Indwelling arterial catheter

• Current patient in the American Family Children's Hospital PICU.

• 1 day to 17.5 years of age

Locations
United States
Wisconsin
American Family Children's Hospital PICU
RECRUITING
Madison
Contact Information
Primary
Meg Baker
meg.baker@wisc.edu
meg.baker@wisc.edu
Time Frame
Start Date: 2026-08-03
Estimated Completion Date: 2028-05
Participants
Target number of participants: 125
Treatments
PICU Patients
Mechanically ventilated pediatric patients (1 day-17.5 years) admitted to the PICU.
Related Therapeutic Areas
Sponsors
Leads: University of Wisconsin, Madison

This content was sourced from clinicaltrials.gov