Cardiogenic Shock Clinical Trials

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Early Intra-aortic Balloon Pump Use After Venoarterial Extracorporeal Membrane Oxygenation: The EASE-ECMO Randomized Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this multicenter, randomized trial is to compare early early left ventricular unloading by Intra-aortic Balloon Pump (IABP) versus conventional approach in patients with cardiogenic shock (CS) undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO). The main question it aims to answer is : • If left ventricular unloading by IABP as compared with the conventional approach will improve the outcomes in patients undergoing VA-ECMO.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age of ≥18

• Cardiogenic shock(defined as a systolic blood pressure of less than 90 mm Hg for more than 30 minutes or the initiation of catecholamines to maintain a systolic pressure of more than 90 mm Hg, an arterial lactate level of more than 3 mmol per liter, and signs of impaired organ perfusion)

• Successful implantation of VA-ECMO

• Informed consent

Locations
Other Locations
China
Beijing Anzhen Hospital
RECRUITING
Beijing
Contact Information
Primary
Xiaotong Hou, MD, PhD
xt.hou@ccmu.edu.cn
010-64456631
Time Frame
Start Date: 2026-03-22
Estimated Completion Date: 2028-12-01
Participants
Target number of participants: 358
Treatments
Experimental: ECMO+IABP group
Patients receive IABP for left ventricular unloading within 6 hours after VA-ECMO initiation.
Active_comparator: ECMO group
Patients do not receive mechanical unloading within 6 hours after VA-ECMO initiation.
Related Therapeutic Areas
Sponsors
Leads: Beijing Anzhen Hospital

This content was sourced from clinicaltrials.gov