Cyclosporine In Takotsubo Syndrome (CIT) Trial
The goal of this clinical trial is to investigate the impact of repetitive acute Cyclosporine A (CsA) bolus therapy in patients suffering from TTS with an elevated risk of impaired outcome. The main question it aims to answer is whether CsA reduces myocardial injury (primary outcome). Participants will receive CsA or placebo at baseline and every 12h in the first 24h after study inclusion. Researchers will compare CsA and the placebo group to see if a) myocardial injury is reduced, and b) ejection fraction is improved compared to baseline, as well as several other secondary endpoints over a one year follow-up.
• Patients aged over 18
• Enrollment and first IMP administration within 24 hours after cardiac catheterization
• Regional Wall Motion Abnormality (WMA) consistent with TTS in angiography or echocardiography
• InterTAK prognostic score- or a GEIST Score ≥ 9 -
• Written informed consent