Characterization of Acute Myocardial Damage With Spectral Computed Tomography. CADAMI-SPECTRAL.

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Clinical management of patients with chest pain and elevation of biomarkers of myocardial injury require an accurate diagnosis. Until now, cardiac magnetic resonance imaging (cMRI) is the gold standard for the diagnosis among myocarditis, stress cardiomyopathy, or inapparent ischemic damage. The development of spectral CT has opened up the possibility of characterizing the coronary anatomy and the myocardium in a single procedure. Our aim is to assess the diagnostic ability of differential patterns in first- pass perfusion and delayed iodine enhancement obtained by spectral CT in patients with acute myocardial injury. This study is designed as a prospective multicenter observational study with diagnostic intervention in 150 patients admitted with clinical indication of a cMRI due to suspicion of myocardial infarction with normal coronary arteries (MINOCA), myocarditis or stress cardiomyopathy who will undergo a CT study with double detector technology in two reference centers. A control group (n=150) with an indication for cardiac CT for another cause without coronary or structural heart disease will be included. The iodine maps obtained by spectral CT will be compared with the findings obtained with cMRI, both with conventional techniques and with artificial intelligence algorithms (deep learning). A year follow-up of the cohort will be carried out to assess whether the findings derived from the CT in this group of patients provide prognostic information

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
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• Age ≥ 18 year.

• Hospital admission due to chest pain and acute myocardial injury.

• Clinical indication for cardiac MRI (CMR) due to suspected acute myocardial infarction with coronary angiography showing no significant lesions (\<50%) (MINOCA), acute myocarditis, or stress-induced cardiomyopathy.

• Signed informed consent.

Locations
Other Locations
Spain
Complejo Asistencial Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca
RECRUITING
Salamanca
Contact Information
Primary
Candelas Perez-Del Villar, MD, PhD
mcperezvi@saludcastillayleon.es
0034 923291100
Time Frame
Start Date: 2022-09-01
Estimated Completion Date: 2025-09-01
Participants
Target number of participants: 300
Treatments
Case
Myocardial tissue characterisation using spectral technology and Cardiac Magnetic Resonance (CMR) imaging.
Controls
Myocardial tissue characterisation using spectral technology and CMR imaging.
Related Therapeutic Areas
Sponsors
Leads: Salamanca University Hospital
Collaborators: Hospital Universitario Ramon y Cajal

This content was sourced from clinicaltrials.gov