Myocardial Perfusion Quantification With Single Photon Emission Computed Tomography Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary Computed Tomography Angiography

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, the investigators aim to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and utilizing myocardial flow reserve calculated from dynamic SPECT images. 50 patients with suspected coronary artery disease are anticipated to be enrolled. Pharmacological stress and rest-phase dynamic and static MPI SPECT following an additional coronary CTA scan are to be performed. The obtained multimodality imaging data (functional and anatomical parameters) are planned to be compared and subjected to statistical analysis. The results of this study are expected to improve risk assessment for patients with moderate cardiovascular risk and enhance the diagnostic performance of MPI SPECT.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• suspected coronary artery disease

• referred to coronary CTA or SPECT MPI by the patient's physician

• agrees to the other imaging modality that was not indicated by their physician (coronary CTA or SPECT MPI)

• suitable for informed consent

Locations
Other Locations
Hungary
Semmelweis University, Medical Imaging Centre
RECRUITING
Budapest
Contact Information
Primary
Pál Maurovich-Horvat, Prof. Dr.
maurovich-horvat.pal@semmelweis.hu
+36206632485
Time Frame
Start Date: 2024-03-06
Estimated Completion Date: 2026-08-30
Participants
Target number of participants: 50
Treatments
Experimental: Consecutive patients with moderate pre-test probability according to CAD consortium
Patients undergo dynamic and static MPI SPECT and cardiac CT within 30-days.
Related Therapeutic Areas
Sponsors
Leads: Semmelweis University

This content was sourced from clinicaltrials.gov