Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronization Therapy (MADURAI CRT)
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk categorized by CMR imaging.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with age ≥18 years
• Typical left bundle branch block as defined by Strauss criteria with LVEF ≤35%
• Heart failure symptoms despite guideline directed medical therapy (GDMT)
Locations
Other Locations
India
Velammal Medical College Hospital and Research Institute
RECRUITING
Madurai
Contact Information
Primary
Shunmuga Sundaram Ponnusamy, MD, FHRS
shunmuga.pgi@gmail.com
+919444712846
Time Frame
Start Date: 2026-08-01
Estimated Completion Date: 2028-07-15
Participants
Target number of participants: 114
Treatments
Experimental: LBBP without defibrillator:
Left bundle branch pacing along with right atrial pacing
Active_comparator: BiV-ICD
Biventricular pacing with defibrillator lead using RV-ICD lead, LV lead and atrial lead
Related Therapeutic Areas
Sponsors
Leads: Velammal Medical College Hospital and Research Institute