Carney ComplexSymptoms, Doctors, Treatments, Advances & More
Carney Complex Overview
Learn About Carney Complex
Carney complex is a disorder that is characterized by changes in skin coloring (pigmentation) and an increased risk of tumors. Many of the signs and symptoms of Carney complex become apparent during adolescence or early adulthood.
Variants (also called mutations) in the PRKAR1A gene cause most cases of Carney complex. This gene provides instructions for making one part (subunit) of an enzyme called protein kinase A, which promotes cell growth and division (proliferation). The subunit produced from the PRKAR1A gene helps control whether protein kinase A is turned on or off.
Carney complex is a rare disorder, although the exact prevalence is unknown. At least 750 affected individuals have been reported in the medical literature. Because Carney complex is rare and the features seen in affected individuals can vary, diagnosis of the condition may be delayed.
Carney complex is typically inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. Approximately 30 percent of Carney complex cases result from new (de novo) variants in the gene that occur during the formation of reproductive cells (eggs or sperm) in an affected individual's parent or during early embryonic development. These affected individuals typically have no history of the disorder in their family.
Texas Health Womens Care
Dr. Mina K. Sinacori was born and raised in suburban Long Island, N.Y. She graduated with her medical degree from New York University School of Medicine, and also earned a Master of Public Health degree while at NYU. She is a board-certified obstetrician and gynecologist.Dr. Sinacori married her college sweetheart and relocated to Houston, Texas, where she completed her OB/GYN residency at Baylor College of Medicine. Prior to joining Texas Health Women's Care, she served as the lead physician in a private practice in the Houston area. Her clinical interests include normal and high-risk pregnancy, contraception, menstrual disorders, breast health, cervical dysplasia, fibroids, robotic/minimally invasive surgery, hormonal therapy, treatment for sexually transmitted infections, and preventative women's healthcare. Her goal is delivering individualized and compassionate care for women of all ages.Dr. Sinacori has served on multiple executive boards and committees involved in patient advocacy and quality care initiatives. She was 2021 President of the Houston Academy of Medicine, 2022-24 Chair of the Texas Medical Association's Council on Health Service Organizations, and 2023 President of Harris County Medical Society, the largest county medical society in the country. She has published research on innovative technologies in maternal-fetal medicine and spoken on many topics including wellness, contraception, public health, and HPV vaccination/virology. Dr. Sinacori believes in the benefits of preventive care and healthy living during pregnancy and throughout life. She is passionate about personalizing her patient care around each woman's unique needs for health and wellness.Dr. Sinacori is a Diplomate of the American Board of Obstetrics & Gynecology and a Fellow of the American College of Obstetricians and Gynecologists. She and her husband have two wonderful children and a close-knit family. She loves animals, cooking, and enjoys the outdoors. Dr. Sinacori is rated as an Advanced provider by MediFind in the treatment of Carney Complex. Her top areas of expertise are Carney Complex, Solitary Fibrous Tumor, Intestinal Leiomyoma, Female Genital Sores, and Intrauterine Device Insertion.
Texas Health Womens Care
Dr. Manisha Parikh has served the health care needs of women in the DFW area since 2006. In addition to her practice, she has served as vice chair of the Obstetrics and Gynecology department at Texas Health HEB since 2021. She is also an assistant professor at Texas Christian University and the University of North Texas Health Science Center School of Medicine in Fort Worth. Dr. Parikh is board-certified in obstetrics and gynecology and holds certification in the da Vinci robotic surgical system. Her clinical interests include adolescent gynecology; minimally invasive and hysteroscopic surgical procedures; and the diagnosis and treatment of pelvic organ prolapse, polycystic ovarian syndrome (PCOS), ectopic pregnancy and hormone imbalance. Dr. Parikh earned her medical degree at Medical College of Georgia in Augusta. She completed her obstetrics and gynecology residency at Baylor College of Medicine in Houston, serving as chief resident in her final year. Dr. Parikh is a Diplomate of the American Board of Obstetrics and Gynecology and a Fellow of the American College of Obstetricians and Gynecologists. She is a member of the Texas Medical Association and Tarrant County Medical Society. Dr. Parikh has been recognized numerous times as a Top Doc by Fort Worth Magazine and Southlake Magazine and as a Mom Approved Doctor by Fort Worth Child Magazine. Dr. Parikh is rated as an Advanced provider by MediFind in the treatment of Carney Complex. Her top areas of expertise are Carney Complex, Solitary Fibrous Tumor, Intestinal Leiomyoma, Intrauterine Device Insertion, and Hormone Replacement Therapy (HRT).
Texas Health Womens Care
Dr. Tina Thai was born and raised in Texas, spending much of her early years in the Austin area before starting her undergraduate studies in Killeen, Texas. She later earned her medical degree at the University of North Texas Health Science Center - Texas College of Osteopathic Medicine in Fort Worth. She completed her Ob/Gyn residency at Texas Tech University Health Science Center Permian Basin in Odessa, where she was chief resident in her final year of training. Dr. Thai has served the women’s care needs of the Plano community since 2021. She evaluates and manages a broad range of obstetrical and gynecological concerns and is skilled in minimally invasive surgical techniques, including robotic-assisted surgeries. Dr. Thai is a member of the American Congress of Obstetricians & Gynecologists and American Medical Association. When not with her patients, she enjoys spending time with her husband and fur baby, Buddy, playing tennis, and doing arts and crafts projects. Dr. Thai is a Fellow of the American College of Obstetricians and Gynecologists. She is also a member of the American Congress of Obstetricians & Gynecologists and American Medical Association. Dr. Thai is rated as an Advanced provider by MediFind in the treatment of Carney Complex. Her top areas of expertise are Solitary Fibrous Tumor, Carney Complex, Intestinal Leiomyoma, Hormone Replacement Therapy (HRT), and Salpingo-Oophorectomy.
Summary: NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility...
Summary: Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs. Their clinical behavior is quite variable, encompassing both benign lesions and aggressive tumors that invade surrounding and/or distant structures. NENs may also cause serious morbidity due to hormone oversecretion. NENs are am...
Published Date: March 10, 2025
Published By: National Institutes of Health


