Carotid artery disease occurs when the carotid arteries become narrowed or blocked.

The carotid arteries provide part of the main blood supply to your brain. They are located on each side of your neck. You can feel their pulse under your jawline.

Carotid stenosis; Stenosis - carotid; Stroke - carotid artery; TIA - carotid artery

Carotid artery disease occurs when fatty material called plaque builds up inside the arteries. This buildup of plaque is called hardening of the arteries (atherosclerosis).

The plaque may slowly block or narrow the carotid artery. Or it may cause a clot to form suddenly. A clot that completely blocks the artery can lead to stroke.

Risk factors for blockage or narrowing of the arteries include:

• Smoking (people who smoke one pack a day double their risk for stroke)
• Diabetes
• High blood pressure
• High cholesterol and triglycerides
• Older age
• Family history of stroke
• Alcohol use
• Recreational drug use
• Trauma to neck area, which may cause a tear in the carotid artery
• Radiation therapy

At early stages, you may not have any symptoms. After plaque builds up, the first symptoms of carotid artery disease may be a stroke or a transient ischemic attack (TIA). A TIA is a small stroke that doesn't cause any lasting damage.

Symptoms of stroke and TIA include:

• Blurred vision
• Confusion
• Loss of memory
• Loss of sensation
• Problems with speech and language, including loss of speech
• Vision loss (partial or complete blindness)
• Weakness in one part of your body
• Problems with thinking, reasoning, and memory

Treatment options include:

• Blood-thinning medicines such as aspirin, clopidogrel (Plavix), warfarin (Coumadin), dabigatran (Pradaxa), or others to lower your risk for stroke
• Medicine and diet changes to lower your cholesterol or blood pressure
• No treatment, other than checking your carotid artery every year

You may have certain procedures to treat a narrowed or blocked carotid artery:

• Carotid endarterectomy -- This surgery removes the plaque buildup in the carotid arteries.
• Carotid angioplasty and stenting -- This procedure opens a blocked artery and places a tiny wire mesh (stent) in the artery to keep it open.

Because there are no symptoms, you may not know you have carotid artery disease until you have a stroke or TIA.

• Stroke is a leading cause of death in the United States.
• Some people who have a stroke recover most or all of their functions.
• Others die of the stroke itself or from complications.
• About one half of people who have a stroke have long-term problems.

Major complications of carotid artery disease are:

• Transient ischemic attack. This occurs when a blot clot briefly blocks a blood vessel to the brain. It causes the same symptoms as stroke. Symptoms last only a few minutes to an hour or two, but no longer than 24 hours. A TIA does not cause lasting damage. TIAs are a warning sign that a stroke may happen in the future if nothing is done to prevent it.
• Stroke. When the blood supply to the brain is partly or completely blocked, it causes a stroke. Most often, this happens when a blood clot blocks a blood vessel to the brain. A stroke can also occur when a blood vessel breaks open or leaks. Strokes can cause long-term brain damage or death.

Go to the emergency room or call the local emergency number (such as 911) as soon as symptoms occur. The sooner you receive treatment, the better your chance for recovery. With a stroke, every second of delay can cause more brain injury.

Here's what you can do to help prevent carotid artery disease and stroke:

• Quit smoking.
• Follow a healthy, low-fat diet with plenty of fresh vegetables and fruits.
• Do not drink more than 1 to 2 alcoholic drinks a day.
• Do not use recreational drugs.
• Exercise at least 30 minutes a day, most days of the week.
• Get your cholesterol checked every 5 years. If you are being treated for high cholesterol, you need to have it checked more often.
• Get your blood pressure checked every 1 to 2 years. If you have high blood pressure, heart disease, diabetes, or you have had a stroke, you need to have it checked more often. Ask your provider.
• Follow your provider's treatment recommendations if you have high blood pressure, diabetes, high cholesterol, or heart disease.

Published Date: July 26, 2021
Published By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

Biller J, Schneck MJ, Ruland S. Ischemic cerebrovascular disease. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 65.

Brott TG, Halperin JL, Abbara S, et al. 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American Stroke Association, American Association of Neuroscience Nurses, American Association of Neurological Surgeons, American College of Radiology, American Society of Neuroradiology, Congress of Neurological Surgeons, Society of Atherosclerosis Imaging and Prevention, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of NeuroInterventional Surgery, Society for Vascular Medicine, and Society for Vascular Surgery. Catheter Cardiovasc Interv. 2013;81(1):E76-E123. PMID: 23281092 pubmed.ncbi.nlm.nih.gov/23281092/.

Meschia JF, Bushnell C, Boden-Albala B, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754-3832. PMID: 25355838 pubmed.ncbi.nlm.nih.gov/25355838/.

Meschia JF, Klaas JP, Brown RD Jr, Brott TG. Evaluation and management of atherosclerotic carotid stenosis. Mayo Clin Proc. 2017;92(7):1144-1157. PMID: 28688468 pubmed.ncbi.nlm.nih.gov/28688468/.

Nguyen TN, Jovin TG, Nogueira RG, Zaidat OO. Principles of neuroendovascular therapy. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 54.

Xu J, Cao Y. Radiation-induced carotid artery stenosis: a comprehensive review of the literature. Interv Neurol. 2014;2(4):183-192. PMID: 25337087 pubmed.ncbi.nlm.nih.gov/25337087/.