Catecholaminergic Polymorphic Ventricular Tachycardia Overview
Learn About Catecholaminergic Polymorphic Ventricular Tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition characterized by an abnormal heart rhythm (arrhythmia). As the heart rate increases in response to physical activity or emotional stress, it can trigger an abnormally fast heartbeat called ventricular tachycardia. Episodes of ventricular tachycardia can cause light-headedness, dizziness, and fainting (syncope). In people with CPVT, these episodes typically begin in childhood.
CPVT most commonly results from mutations in two genes, RYR2 and CASQ2. RYR2 gene mutations cause about half of all cases, while mutations in the CASQ2 gene account for up to 5 percent of cases. Mutations in other genes are rare causes of the condition.
The prevalence of CPVT is estimated to be about 1 in 10,000 people. However, the true prevalence of this condition is unknown.
When CPVT results from mutations in the RYR2 gene, it follows an autosomal dominant inheritance pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In about half of cases, an affected person inherits an RYR2 gene mutation from one affected parent. The remaining cases result from new (de novo) mutations in the RYR2 gene that occur during the formation of reproductive cells (eggs or sperm) in an affected individual's parent or in early embryonic development. These cases occur in people with no history of the disorder in their family.
Practice Associates Medical Group
Stephen Winters is a Cardiac Electrophysiologist and a Cardiologist in Morristown, New Jersey. Dr. Winters and is rated as a Distinguished provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. His top areas of expertise are Ventricular Fibrillation, Arrhythmias, Ventricular Tachycardia, Pacemaker Implantation, and Cardiac Ablation.
Practice Associates Medical Group
Jay Curwin is a Cardiac Electrophysiologist and a Cardiologist in Morristown, New Jersey. Dr. Curwin and is rated as a Distinguished provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. His top areas of expertise are Arrhythmias, Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Pacemaker Implantation, and Cardiac Ablation.
Practice Associates Medical Group
Philip Rogers is a Cardiologist in Dover, New Jersey. Dr. Rogers and is rated as an Experienced provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. His top areas of expertise are Hypertensive Heart Disease, Pediatric Myocarditis, Coronary Heart Disease, and Atherosclerosis.
Published Date: July 01, 2020
Published By: National Institutes of Health