Catecholaminergic Polymorphic Ventricular TachycardiaSymptoms, Doctors, Treatments, Advances & More
Learn About Catecholaminergic Polymorphic Ventricular Tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition characterized by an abnormal heart rhythm (arrhythmia). As the heart rate increases in response to physical activity or emotional stress, it can trigger an abnormally fast heartbeat called ventricular tachycardia. Episodes of ventricular tachycardia can cause light-headedness, dizziness, and fainting (syncope). In people with CPVT, these episodes typically begin in childhood.
CPVT most commonly results from mutations in two genes, RYR2 and CASQ2. RYR2 gene mutations cause about half of all cases, while mutations in the CASQ2 gene account for up to 5 percent of cases. Mutations in other genes are rare causes of the condition.
The prevalence of CPVT is estimated to be about 1 in 10,000 people. However, the true prevalence of this condition is unknown.
When CPVT results from mutations in the RYR2 gene, it follows an autosomal dominant inheritance pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In about half of cases, an affected person inherits an RYR2 gene mutation from one affected parent. The remaining cases result from new (de novo) mutations in the RYR2 gene that occur during the formation of reproductive cells (eggs or sperm) in an affected individual's parent or in early embryonic development. These cases occur in people with no history of the disorder in their family.
Electrophysiology Associates
Stephen Winters is a Cardiac Electrophysiologist and a Cardiologist practicing medicine in Morristown, New Jersey. Dr. Winters is rated as a Distinguished provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Ventricular Fibrillation, Arrhythmias, Ventricular Tachycardia, Pacemaker Implantation, and Cardiac Ablation. Dr. Winters is board certified in American Board Of Internal Medicine. Dr. Winters is currently accepting new patients.
Prisma Health Cardiology – 8 Med Park 300
Walter Mazzei is a Cardiologist practicing medicine in Columbia, South Carolina. Dr. Mazzei is rated as a Distinguished provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. He is also highly rated in 25 other conditions, according to our data. His clinical expertise encompasses Arrhythmias, Sick Sinus Syndrome, Ventricular Tachycardia, Pacemaker Implantation, and Cardiac Ablation. Dr. Mazzei is board certified in American Board Of Internal Medicine. Dr. Mazzei is currently accepting new patients.
Intermountain Health Heart & Vascular - 360 West Park Cardiology
Trey Moore is a Cardiologist practicing medicine in Grand Junction, Colorado. Dr. Moore is rated as a Distinguished provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. He is also highly rated in 27 other conditions, according to our data. His clinical expertise encompasses Familial Progressive Cardiac Conduction Defect, Atrial Fibrillation, Ventricular Tachycardia, Pacemaker Implantation, and Cardiac Ablation. Dr. Moore is board certified in American Board Of Internal Medicine , American Board Of Internal Medicine , and American Board Of Internal Medicine. Dr. Moore is currently accepting new patients.
Published Date: July 01, 2020
Published By: National Institutes of Health