Caudal regression syndrome is a disorder that impacts the development of the lower (caudal) part of the spine. The condition can affect many parts of the lower body, including the lower back and limbs, the genitourinary tract, and the gastrointestinal tract.

Caudal regression syndrome is a complex condition that may have different causes in different people. The condition is likely caused by the interaction of multiple genetic and environmental factors. One risk factor for the development of caudal regression syndrome is the presence of diabetes during pregnancy. It is thought that increased blood sugar (glucose) levels and other metabolic problems related to diabetes may have a harmful effect on a developing fetus, increasing the likelihood of developing caudal regression syndrome. The risks to the fetus are further increased if the diabetes is poorly managed. Researchers are trying to identify other factors that contribute to the development of this complex disorder.

The frequency of caudal regression syndrome is unknown. It is estimated to occur in 1 to 2.5 in 100,000 newborns. This condition is much more common among infants whose parent has diabetes while pregnant, affecting an estimated 1 in 350 newborns in this group.

Caudal regression syndrome occurs sporadically, which means it occurs in people with no history of the condition in their family. Multiple genetic and environmental factors likely affect the risk of developing this condition.

Published Date: September 12, 2023
Published By: National Institutes of Health