What is the definition of Cavernous Sinus Thrombosis?

Cavernous sinus thrombosis is a blood clot in an area at the base of the brain.

What are the causes for Cavernous Sinus Thrombosis?

The cavernous sinus receives blood from veins of the face and brain. The blood drains it into other blood vessels that carry it back to the heart. This area also contains nerves that control vision and eye movements.

Cavernous sinus thrombosis is most often caused by a bacterial infection that has spread from the sinuses, teeth, ears, eyes, nose, or skin of the face.

You are more likely to develop this condition if you have an increased risk of blood clots.

What are the symptoms for Cavernous Sinus Thrombosis?

Symptoms include:

  • Bulging eyeball, usually on one side of face
    Bulging eyeball, usually on one side of face
  • Cannot move the eye in a particular direction
    Cannot move the eye in a particular direction
  • Drooping eyelids
    Drooping eyelids
  • Headaches
    Headaches
  • Vision loss
    Vision loss

What are the current treatments for Cavernous Sinus Thrombosis?

Cavernous sinus thrombosis is treated with high-dose antibiotics given through a vein (IV) if an infection is the cause.

Blood thinners help dissolve the blood clot and prevent it from getting worse or recurring.

Surgery is sometimes needed to drain the infection.

What is the outlook (prognosis) for Cavernous Sinus Thrombosis?

Cavernous sinus thrombosis can lead to death if left untreated.

When should I contact a medical professional for Cavernous Sinus Thrombosis?

Call your health care provider right away if you have:

  • Bulging of your eyes
    Bulging of your eyes
  • Drooping eyelids
    Drooping eyelids
  • Eye pain
    Eye pain
  • Inability to move your eye in any particular direction
    Inability to move your eye in any particular direction
  • Vision loss
Sinuses

REFERENCES

Chow AW. Infections of the oral cavity, neck, and head. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 64.

Markiewicz MR, Han MD, Miloro M. Complex odontogenic infections. In: Hupp JR, Ellis E, Tucker MR, eds. Contemporary Oral and Maxillofacial Surgery. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 17.

Nath A, Berger JR. Brain abscess and parameningeal infections. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 385.

  • Condition: Chronic Orbital and Calvarial Fungal Infection with Apophysomyces Variabilis in Immunocompetent Patient
  • Journal: Survey of ophthalmology
  • Treatment Used: Surgery and Antifungal Treatment
  • Number of Patients: 1
  • Published —
This case report describes a 74-year-old immunocompetent woman diagnosed with chronic orbital and calvarial fungal infection with Apophysomyces variabilis treated with antifungal therapy.